Tag: <span>Alzheimer’s disease</span>

Home / Alzheimer’s disease
Post

Alzheimer’s disease—why insulin is a new suspect

Johnson and Johnson recently announced that it was halting a clinical trial for a new Alzheimer’s drug after safety issues emerged. This latest failure adds to the dozens of large, costly clinical trials that have shown no effect in treating this devastating disease. The growing list of failures should give us pause for thought – have we...

Post

A typical communication pattern of people with Alzheimer’s disease

Dementia, in any form, is a heartbreaking disease that can take away one’s thinking and judgment abilities before they pass. To save face, people with dementia often pretend to know answers to questions, even if they really don’t. This often hides the severity of the disease and exasperates the fears and frustrations of the people...

Post

Scientists fix genetic risk factor for Alzheimer’s disease in human brain cells

PET scan of a human brain with Alzheimer’s disease.    Using human brain cells, scientists at the Gladstone Institutes discovered the cause of—and a potential solution for—the primary genetic risk factor for Alzheimer’s disease, a gene called apoE4. Having one copy of the apoE4 gene more than doubles a person’s likelihood of developing Alzheimer’s disease, and...

Post

Benzodiazepines increase mortality in persons with Alzheimer’s disease

Benzodiazepine and related drug use is associated with a 40 percent increase in mortality among persons with Alzheimer’s disease, according to a new study from the University of Eastern Finland. The findings were published in the International Journal of Geriatric Psychiatry. The study found that the risk of death was increased right from the initiation...

Post

PSEN1 Mutant iPSC-Derived Model Reveals Severe Astrocyte Pathology in Alzheimer’s Disease

Highlights PSEN1 mutant AD astrocytes manifest hallmarks of AD pathology Altered mitochondrial metabolism in AD astrocytes increases oxidative stress AD astrocytes reduce the calcium signaling activity of healthy neurons Astrocytes are important in the pathogenesis of AD Summary Alzheimer’s disease (AD) is a common neurodegenerative disorder and the leading cause of cognitive impairment. Due to insufficient...

Post

New player in Alzheimer’s disease pathogenesis identified

PET scan of a human brain with Alzheimer’s disease.    Scientists at Sanford Burnham Prebys Medical Discovery Institute (SBP) have shown that a protein called membralin is critical for keeping Alzheimer’s disease pathology in check. The study, published in Nature Communications, shows that membralin regulates the cell’s machinery for producing beta-amyloid (or amyloid beta, Aβ), the...

Post

An Eye Scan for Alzheimer’s Disease?

Researchers aim for a routine screen to detect the neurodegenerative disease—decades before symptoms appear. Neurodegenerative diseases are tough nuts to crack, not just because of the inherent difficulties of sorting through what has gone awry, and why, but also due to a dearth of biomarkers that could help spot the diseases and track their progression....

Post

Clinical trial finds blood-plasma infusions for Alzheimer’s safe, promising

In a small safety trial based on preclinical work by a Stanford researcher, participants receiving blood plasma infusions from young donors showed some evidence of improvement. Sharon Sha presented findings Nov. 4 from a small clinical trial that found administering blood plasma from young donors to people with mild to moderate Alzheimer’s disease was safe....