Diagram of the brain of a person with Alzheimer’s Disease. Working with human brain tissue samples and genetically engineered mice, Johns Hopkins Medicine researchers together with colleagues at the National Institutes of Health, the University of California San Diego Shiley-Marcos Alzheimer’s Disease Research Center, Columbia University, and the Institute for Basic Research in Staten...
Tag: <span>Alzheimer’s disease</span>
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‘Silent seizures’ discovered in patients with Alzheimer’s disease
On the left is Dr. Alica Goldman and on the right is Dr. Jeffrey Noebels. Deep in the brains of two patients with Alzheimer’s disease, the main memory structure, the hippocampus, displays episodic seizure-like electrical activity. These non-convulsive hippocampal seizures are the first signs of ‘silent’ brain electrical network dysfunction described in patients with...
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Detecting Alzheimer’s disease earlier using … Greebles?
Which Greeble is different? Unique graphic characters called Greebles may prove to be valuable tools in detecting signs of Alzheimer’s disease decades before symptoms become apparent. In an article published online last week in Journal of Alzheimer’s Disease, Emily Mason, Ph.D., a postdoctoral associate in the Department of Neurological Surgery at the University of Louisville,...
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Ultrasound and drug research holds promise for Alzheimer’s disease
Three dimensional imaging of the blood-brain barrier. Non-invasive ultrasound improves the delivery to the brain of a therapeutic antibody targeting Alzheimer’s disease, University of Queensland researchers have found. Scientists from UQ’s Queensland Brain Institute (QBI), previously showed non-pharmacological scanning ultrasound reversed Alzheimer’s symptoms and restored memory in mice. The new research found that ultrasound alone cleared...
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Never before seen images of early stage Alzheimer’s disease
Images that predate the formation of toxic clumps of beta-amyloid, the protein believed to be at the root of Alzheimer’s disease, have now been captured by researchers. Researchers at Lund University in Sweden have used the MAX IV synchrotron in Lund — the strongest of its kind in the world — to produce images that...
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Sugar’s ‘tipping point’ link to Alzheimer’s disease revealed
For the first time a “tipping point” molecular link between the blood sugar glucose and Alzheimer’s disease has been established by scientists, who have shown that excess glucose damages a vital enzyme involved with inflammation response to the early stages of Alzheimer’s. Abnormally high blood sugar levels, or hyperglycaemia, is well-known as a characteristic of diabetes and...
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More Than 9 Hours Of Sleep Could Indicate Alzheimer’s Disease: Here Are Other Warning Signs Of Dementia
Sleep is essential to health but findings of a new study suggest that prolonged sleeping may also indicate dementia. Dementia Dementia is a condition marked by loss of memory and other mental abilities grave enough to interfere with daily life. The condition is caused by physical changes in the brain. The most common type of...
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Calcium imbalance within brain cells may trigger Alzheimer's disease
New research investigates the role of calcium production in Alzheimer’s disease. The neurodegenerative process may be caused by a calcium imbalance within the brain cell. New research suggests that a calcium processing dysfunction in the neurons’ mitochondria may drive Alzheimer’s disease. Mitochondria – sometimes referred to as the “powerhouse of the cell” – are small...
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New drug SAK3 may offer hope to Alzheimer's disease patients
Acetylcholine is a neurotransmitter in the brain that plays an important role in controlling attention and cognition. Acetylcholine system dysfunction is believed to be one of the causes of Alzheimer’s disease (AD) and vascular dementia. Now, a new drug that could treat Alzheimer’s disease, SAK3, has been developed by a Japanese research group led by...