by Salk Institute Neurons (green) derived from a patient with Alzheimer’s disease. The nuclei (blue) of the neurons are also shown. Credit: Salk Institute Despite decades of research, Alzheimer’s disease remains a debilitating and eventually fatal dementia with no effective treatment options. More than 95 percent of Alzheimer’s disease cases have no known origin. Now,...
by Indiana University School of Medicine Pharmacokinetic analysis of levetiracetam (LEV) in 6-month aged 5XFAD mice reveals significant sex differences. A, Plasma concentration time profiles of LEV by dose and sex in 5XFAD males and females. B, One-compartment model fit for the 30 mg/kg dose. C, Volume of distribution (V/F) and clearance (CL/F) is shown....
by Lund University Visual representation of the role of microglia activation in longitudinal accumulation of amyloid and tau aggregates. When microglia are in a homeostatic state, they do not protect against the accumulation of amyloid and tau aggregates, which increase over time in individuals at risk of developing Alzheimer’s disease (AD) (a). In contrast, when...
by Frontiers Credit: Unsplash/CC0 Public Domain Alzheimer’s disease can remain undetected until it is too late to treat. Large-scale screening programs could help to detect early-stage disease, but current diagnostic methods are too cumbersome and expensive. Now, a new study is the first to identify formic acid as a sensitive urinary biomarker that can reveal...
by The Mount Sinai Hospital Cst7 (yellow) is a Plaque Induced Gene (PIG) and its expression is specific to plaques in the INPP5D knockdown mouse (right), vs an AD mouse with normal levels of INPP5D (left). Credit: Emilie Castranio, PhD, postdoctoral fellow at the Icahn School of Medicine at Mount Sinai and co-first author of...
by Indiana University School of Medicine A high-molecular-weight tau seed interacts with BSN protein. a, Schematic of the tau-seeding assay of SEC fractions. b, Tau-seeding activity of SEC fractions obtained from 3-month-old PS19 and WT mouse brain lysates. c, Total human tau (hTau) detected by ELISA in SEC fractions from PS19 and WT mouse brain lysates. d, Tau-seeding activity...
by Washington University School of Medicine Red and orange areas on these heat maps of human brains show where the gene APOE is most active (top two brain images) and where tangles of the protein tau are most concentrated (bottom two brain images). APOE is the biggest genetic risk factor for Alzheimer’s, and tau tangles...
POHANG UNIVERSITY OF SCIENCE & TECHNOLOGY (POSTECH) IMAGE: GOSSYPETIN ADMINISTRATION AND THE SUBSEQUENT CHANGES IN THE BRAIN TISSUE AFFECTED BY ALZHEIMER’S DISEASE. CREDIT: POSTECH A Cup of ruby red hibiscus tea not only warms the body in winter but also is known to boost the immune system, control blood pressure, and reduce body weight. And...
by Technical University Munich Proposed mechanism and hypothetical models of IAPP/ACM nanofiber co-assembly versus IAPP amyloid self-assembly. The lower part, IAPP self-assembly into toxic oligomers and amyloid fibrils. The upper part, in the presence of ACMs, IAPP monomers/prefibrillar species are redirected into initially amorphous and non-toxic hetero-assemblies, which convert into amyloid fibril-resembling but ThT-invisible and...
by American Chemical Society Graphical abstract. Credit: ACS Chemical Neuroscience (2022). DOI: 10.1021/acschemneuro.2c00342 A definitive diagnosis of Alzheimer’s disease (AD) was once only possible after someone had died, but recent biomarker studies have led to the development of imaging and spinal fluid tests for those still living. However, the tests can only monitor severe disease, differentiating advanced...
