by Indiana University School of Medicine Accelerated plaque deposition in 5xFAD mice deficient in Cx3cr1. (A) Accumulation of MOAB2+ Aβ42 plaques in (top panels) 4 month-old vs. (bottom panels) 6 month-old 5xFAD;Cx3cr1+/+ and 5xFAD; Cx3cr1−/− mice. Scale bars = 500 μm. Quantification of %MOAB2+ areas in the (B) cortex and (C) hippocampus of 4 and 6 month-old 5xFAD;Cx3cr1+/+ (black bars) and 5xFAD;Cx3cr1−/− (gray bars) mice. Data in B,C represent...
by University of York Diagram of the brain of a person with Alzheimer’s Disease. Credit: Wikipedia/public domain. Scientists have used a mathematical model to reveal how toxic proteins cluster together inside the brain during the early stages of Alzheimer’s. The researchers, from the University of York’s School of Physics, Engineering and Technology, say the discovery...
by Cleveland Clinic Cleveland Clinic-led study identifies blood pressure drug as potential treatment for Black patients with Alzheimer’s disease. Credit: Cleveland Clinic Considering how patients from different ethnic groups respond to the same drug could be crucial to finding new Alzheimer’s disease treatments—a disorder the Alzheimer’s Association previously deemed a “silent epidemic” among Black adults....
INDIANA UNIVERSITY SCHOOL OF MEDICINE INDIANAPOLIS—Indiana University School of Medicine researchers are investigating how the deficiency of a gene in immune cells can shape the progression of Alzheimer’s disease. The study, published in Molecular Degeneration, found that deleting CX3CR1, a microglial gene associated with neurodegenerative diseases, in Alzheimer’s disease animal models resulted in an aggravated disease...
by CU Anschutz Medical Campus Credit: iScience (2022). DOI: 10.1016/j.isci.2022.105288 The overexpression of a gene tied to cell division and the structure and function of neurons may prevent and protect against cognitive decline in both mice and humans with Alzheimer’s disease (AD), according to a new study by scientists at the University of Colorado Anschutz Medical Campus....
by Society of Nuclear Medicine Graphical abstract. 18F-SMBT-1 PET studies showed that Ab+ Alzheimer’s disease (AD) patients, but most importantly, Ab+ controls (CN) have significantly higher regional 18F-SMBT-1 binding than Ab- CN, with 18F-SMBT-1 retention highly associated with Ab burden. These findings suggest that increased 18F-SMBT-1 binding is detectable at the preclinical stages of Ab accumulation. Credit: Journal of Nuclear...
by St. Jude Children’s Research Hospital Credit: Pixabay/CC0 Public DomainResearchers have puzzled over the neurodegenerative disorder Alzheimer’s disease for decades, but treatments to stop or reverse the disease’s effects on the brain have remained elusive. Scientists at St. Jude Children’s Research Hospital recently added an important piece to the puzzle by creating a mouse model...
Reviewed by Emily Henderson, B.Sc. Oct 4 2022 Case Western Reserve University researchers have identified a mechanism in brain tissue that may explain why women are more vulnerable to Alzheimer’s disease-;a finding that they say could help lead to new medicines to treat the disease. Specifically, the researchers found that the female brain shows higher...
by University of Cincinnati PET scan of a human brain with Alzheimer’s disease. Credit: public domain New research from the University of Cincinnati bolsters a hypothesis that Alzheimer’s disease is caused by a decline in levels of a specific protein, contrary to a prevailing theory that has been recently called into question. UC researchers led...
UNIVERSITY OF MALAGA IMAGE: INES MORENO, SCIENTIST OF THE UMA, PROPOSES THE REMOVAL OF TOXIC PROTEINS IN THE BRAIN, THE MAIN CAUSE OF NEURONAL DEATH, AT A CIRCULATORY LEVEL CREDIT: UNIVERSITY OF MALAGA A new study conducted by the scientist of the UMA Inés Moreno, in collaboration with the University of Texas, has identified a...
