by Taylor McNeil, Tufts University “In the case of these compounds that passed the screening, they had virtually no plaques visible after about a week,” says Dana Cairns. This image shows effects of resveratrol compared to control. Credit: Dana Cairns Alzheimer’s disease is the sixth leading cause of death in the United States, affecting more...
by The Scripps Research Institute Depletion of cholesterol in astrocytes (right) directly removes amyloid plaques and phosphorylated Tau (left, orange clusters) in an Alzheimer’s mouse model. Credit: Scott Hansen Lab, Scripps Research, Jupiter, Florida. A team co-led by scientists at Scripps Research has used advanced imaging methods to reveal how the production of the Alzheimer’s-associated protein amyloid beta (Aβ) in the...
Salk scientists find brain’s immune cells form some plaques as a defense in Alzheimer’s, suggesting a new therapeutic direction One of the characteristic hallmarks of Alzheimer’s disease (AD) is the buildup of amyloid-beta plaques in the brain. Most therapies designed to treat AD target these plaques, but they’ve largely failed in clinical trials. New research by Salk...
by Salk Institute A dense-core amyloid-beta plaque (red) surrounded by microglia that lack TAM receptors (white) in the brain of a mouse with Alzheimer’s disease. Credit: Salk Institute One of the characteristic hallmarks of Alzheimer’s disease (AD) is the buildup of amyloid-beta plaques in the brain. Most therapies designed to treat AD target these plaques, but...
