by Rutgers University Graphical abstract. Credit: Cell Stem Cell (2022). DOI: 10.1016/j.stem.2022.06.007 Rutgers scientists have found more clear-cut evidence of how the destructive proteins linked to Alzheimer’s disease attack human brain cells and destroy surrounding tissue. In one of the first studies of its kind examining human brain cells grown in a mouse brain, researchers identified a pivotal mechanism that...
The bacteria, fusobacterium nucleatum (F. nucleatum), proliferates in periodontal disease and affects the gums and jawbone. If untreated, it results in unstable teeth and tooth loss. In recent years, studies have linked F. nucleatum to conditions ranging from colorectal cancer to premature delivery of babies. “In this study, our lab is the first to find that Fusobacterium nucleatum can generate systemic inflammation and...
Written by Cherilyn Cecchini, MD | Reviewed by Katie E. Golden, MDPublished on June 2, 2022 Key takeaways: There are many different types of dementia, but they all cause forgetfulness, trouble thinking clearly, and difficulty controlling emotions. Alzheimer’s disease is the most common type of dementia. Early signs of Alzheimer’s dementia include new memory loss,...
A new article describes common misconceptions about living with Alzheimer’s disease. FG Trade/Getty Images A diagnosis of Alzheimer’s disease and the early symptoms associated with the condition can sometimes cause feelings of frustration, anger, or social withdrawal. Stigma and misperceptions about Alzheimer’s disease can negatively impact social interaction between friends and family members and individuals...
UNIVERSITY OF CALIFORNIA – SAN FRANCISCO In a new study of Alzheimer’s disease, researchers at UC San Francisco have discovered that a relatively unstudied form of the tau protein associated with neurodegeneration may be a means for better diagnosis and treatment of the disease. The form of tau, which is broken into fragments that accumulates...
by Bill Hathaway, Yale University PET scan of a human brain with Alzheimer’s disease. Credit: public domain An experimental drug restored brain synapses in two mouse models of Alzheimer’s disease, raising hopes that it could help revive cognitive function in human dementia patients, Yale University researchers report June 1 in the journal Science Translational Medicine. While...
by Dennis Thompson The APOE4 gene is the most powerful genetic factor driving a person’s risk for developing late-onset Alzheimer’s disease. “It probably increases your risk two or threefold if you have one APOE4 copy, and if you have two APOE4 copies, it probably increases your risk about tenfold,” said Dr. Michael Greicius, a professor of...
by Columbia University Irving Medical Center Diagram of the brain of a person with Alzheimer’s Disease. Credit: Wikipedia/public domain. For more than 20 years, scientists have known that people with hypertension, diabetes, high cholesterol, or obesity have a higher likelihood of developing Alzheimer’s disease. The conditions can all affect the brain, damaging blood vessels and leading...
by Skolkovo Institute of Science and Technology Experiment scheme and the results of the study: transgenic mice with Alzheimer’s disease-like beta-amyloid plaques in the brain. The degree of isomerization of beta-amyloid peptides (vertically) is determined by the intensity of the mass spectrometric signal (horizontally). The results obtained for the human brain (green dot) are consistent with...
DZNE – GERMAN CENTER FOR NEURODEGENERATIVE DISEASES Subjective memory disorders in conjunction with conspicuous levels of beta-amyloid proteins in the cerebrospinal fluid are a strong indication of developing Alzheimer’s disease. This is the conclusion of a DZNE study involving about 1,000 older adults. A team led by dementia researcher Frank Jessen reports on these findings...
