MAY 31, 2024 by Washington University in St. Louis Credit: Pixabay/CC0 Public Domain The protein sTREM2 plays a crucial role in Alzheimer’s disease, but the role is complex and poorly understood. In the early stages of the disease, sTREM2 levels in the cerebrospinal fluid fall relative to healthy people’s, but then the levels rise far...
by Ali Davis, University of Southern California MAY 17, 2024 Piezo 1 Activation Decreases the CDH5-stained Area and Increases Drainage of Lymphatic Vessel Mimetics in Polydimethylsiloxane (PDMS) Chip. (a) Schematic illustration of the 3D lymphatic vessel model used for this study. (b) Fluorescence confocal images of the engineered lymphatic vessels stained for F-actin and CDH5....
by F.D. Flam, Bloomberg Opinion Credit: Pixabay/CC0 Public DomainA few years ago, researchers made the unnerving discovery that in the brains of people with Alzheimer’s disease, disordered clumps of abnormal proteins had been growing for 15 or even 20 years before their diagnosis. That means these pathological-looking deposits are silently accumulating in the brains of...
by University of Sharjah Credit: Pixabay/CC0 Public DomainPeople who fast intermittently and observe Ramadan, the Muslim month of fasting, may lower the risk of age-related neurodegenerative diseases such as Alzheimer and Parkinson’s, according to a study published in the journal Medicina. The literature dwells on the positive interaction between intermittent fasting and brain-derived neurotrophic factor (BDNF),...
by Sarah McQuate, University of Washington Microscopy image of beta cells making IAPP (left) and IAPP plus one of the team’s synthetic peptides (right). Credit: Protein Science (2023). DOI: 10.1002/pro.4854Of the 38 million Americans who have diabetes, at least 90% have type 2, according to the Centers for Disease Control and Prevention. Type 2 diabetes occurs...
Andrew N. Wilner, MD; Ronald C. Petersen, MD, PhDDISCLOSURES Andrew N. Wilner, MD: Welcome to Medscape. I’m Dr Andrew Wilner. Today I have a special guest: Dr Ron Petersen. Dr Petersen is the lead author of a paper recently published in JAMA Neurology, entitled, “A New Framework for Dementia Nomenclature.” Welcome, Dr Petersen. Ronald C....
Stimulating a key brain rhythm with light and sound increases peptide release from interneurons, driving clearance of Alzheimer’s protein via the brain’s glymphatic system, new study suggestsPeer-Reviewed Publication PICOWER INSTITUTE AT MIT BRIGHT STAINING HIGHLIGHTS VIP-EXPRESSING INTERNEURONS IN THIS CORONAL CROSS-SECTION OF A MOUSE BRAIN. THE NEURONS MAY HELP DRIVE GLYMPHATIC CLEARANCE OF AMYLOID VIA...
by Douglas Johnson, Medical University of South Carolina Credit: Pixabay/CC0 Public DomainAs the years add up, it’s common to notice slight changes in our ability to remember and think. Older people who have more marked changes than their peers can be diagnosed with mild cognitive impairment (MCI). Currently, we can’t easily predict which of these patients...
by University of North Carolina at Chapel Hill Chirality inversion mechanisms. Scheme and TEM images (a) of Fmoc-FFFF-PEG2 prepared at RT, or heated to 37 and 40 °C to track the chirality inversion (50 nm scale bars). Schematic (b) of seeded growth via right-handed nucleation points. CD spectra (c) of nucleated assemblies grown with varying monomer:seed ratios. TEM...
by Andrew Smith, Rutgers University Graphical abstract. Credit: Journal of Clinical Investigation (2023). DOI: 10.1172/JCI171468A team of Rutgers undergraduates has shown that an experimental drug known as Yoda1 may help drain cranial waste plus neurotoxins that cause Alzheimer’s disease and other forms of dementia. “The brain’s lymphatic system is one of the hottest research areas in...
