by RUDN University Biochemists from RUDN University (Russia) and the University of Bari (Italy) report a group of compounds that can become a molecular scaffold for new drugs for Alzheimer’s disease. They have demonstrated that derivatives of 1,2,3,4,5,6-hexahydroazepino[4,3-b]indole, or HHAI, are effective inhibitors of acetylcholinesterase and butyrylcholinesterase—enzymes whose increased activity can worsen the condition in...
Tag: <span>Alzheimers</span>
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Tracking Alzheimer’s disease pathology in single neuronal cells
UNIVERSITY OF WARWICK Aggregates of Tau protein in the brain are a hallmark of neurodegeneration, particularly in Alzheimer’s disease. Researchers at the University of Warwick have introduced fluorescently labelled Tau aggregates (oligomers) into single brain neurons and were able to track their movement and effects. They found the introduced Tau oligomers interfered with the action potential waveform, modified the...
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Is copper a cause of Alzheimer’s disease?
University of Houston researcher examines the link UNIVERSITY OF HOUSTON A University of Houston chemist is exploring the link between copper protein molecules in brain cells and neurodegenerative diseases like Alzheimer’s. “Scientists have studied Alzheimer’s disease for 100 years and still no one knows the cause,” said assistant professor of chemistry Tai-Yen Chen, who will...
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Alzheimer’s research increasingly focused on links to sleep and other behaviors
by Elsevier Sleep and other behavioral topics are growing within Alzheimer’s disease research, according to a new report released today by Elsevier, a global information analytics business specializing in science and health. To coincide with World Alzheimer’s Month, Elsevier analyzed Alzheimer’s research published since the 1970s offering a comprehensive view of the landscape of Alzheimer’s...
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Scientists link ‘hunger hormone’ to memory in Alzheimer’s study
UNIVERSITY OF TEXAS AT DALLAS Scientists at The University of Texas at Dallas have found evidence suggesting that resistance to the “hunger hormone” ghrelin in the brain is linked to the cognitive impairments and memory loss associated with Alzheimer’s disease (AD). The findings, based on observations of postmortem brain-tissue samples from Alzheimer’s patients and on experiments with a mouse model of AD, also...
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Link between paid employment and slower age-related memory decline
by Alzheimer’s Research UK Over the past century, patterns of employment, marriage and parenthood have changed drastically for women across the Western World. In a study presented today at the Alzheimer’s Association Internal Conference 2019, researchers have explored how differences in life experiences affect later life memory decline. A team of researchers from the University of California looked at...
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The Startling Link Between Sugar and Alzheimer’s
A high-carb diet, and the attendant high blood sugar, are associated with cognitive decline. In recent years, Alzheimer’s disease has occasionally been referred to as “type 3” diabetes, though that moniker doesn’t make much sense. After all, though they share a problem with insulin, type 1 diabetes is an autoimmune disease, and type 2 diabetes is a chronic...
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Alzheimer’s blood test almost ‘usable in routine clinical care’
By Ana Sandoiu Fact checked by Jasmin Collier New research shows that a blood test for Alzheimer’s disease accurately detected levels of beta-amyloid protein in all stages of the condition, approaching “a level of accuracy that is usable in routine clinical care around the world.” The brain changes that lead to the symptoms of Alzheimer’s...
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COULD GENE MODIFICATION BE A SKELETON KEY FOR CURING ALZHEIMER’S?
While CRISPR technology is generating a new wave of optimism for curing neurological diseases, experts warn that it has to be one part of a larger approach. TARA FERNANDEZ It’s hard to ignore the fanfare. CRISPR and other genome-editing technologies are set to redefine the way we treat a vast array of illnesses, from cancer to inherited...
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Supplements for brain health show no benefit – a neurologist explains a new study
by Steven Dekosky, The Conversation Americans and others around the world have turned increasingly to dietary supplements in order to maintain or preserve their brain health. A recent study found that a quarter of adults over 50 take a supplement for brain-related health. But that same study, done by experts convened by the AARP, suggests that seniors should spend their money elsewhere. The supplements don’t work....