by Sandra-Ilona Sunram-Lea, The Conversation Dementia is a cruel disease that robs people of their memory, their judgement and their identity. Unfortunately, there is no cure, and in the past few years a number of clinical trials for new dementia drugs have failed – the latest being Biogen’s drug aducanumab. Without any effective treatments on the...
Tag: <span>Alzheimers</span>
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Alzheimer’s-like symptoms reversed in mice, researchers say
Credit: CC0 Public Domain A diet containing compounds found in green tea and carrots reversed Alzheimer’s-like symptoms in mice genetically programmed to develop the disease, USC researchers say. Researchers emphasize that the study, recently published in the Journal of Biological Chemistry, was in mice, and many mouse discoveries never translate into human treatments. Nevertheless, the findings lend credence to...
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Identification of potential target protein aggregates for treating Alzheimer’s
The aggregation of alpha-synuclein proteins in Parkinson’s disease and tau proteins in Alzheimer’s disease is intimately linked to the progression of these neurodegenerative diseases. These aggregates propagate from one neuronal cell to another, attaching themselves to the cells. They multiply during this propagation. It has already been shown that the propagation and amplification of these...
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A gentle method for unlocking the mysteries of the deep brain
The electroencephalogram records the electrical activity of the brain in a non-invasive way using 256 electrodes placed on the scalp. Thanks to mathematical algorithms combined with anatomical imaging, we can see what is happening in the deepest part of our brain, without having to enter it directly. Credit: UNIGE The subcortical areas of the brain, situated in its deepest...
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Brain discovery explains a great mystery of Alzheimer’s, Parkinson’s
One of the great mysteries of neuroscience may finally have an answer: Scientists at the University of Virginia School of Medicine have identified a potential explanation for the mysterious death of specific brain cells seen in Alzheimer’s, Parkinson’s and other neurodegenerative diseases. The new research suggests that the cells may die because of naturally occurring...
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FDA: Young-blood transfusions provide ‘no proven clinical benefit’ for aging, Alzheimer’s
The quest to rejuvenate aging people with the blood of young donors has generated paying customers, captured the popular imagination, and, now, prompted a warning from the Food and Drug Administration. Scientific American The agency on Tuesday said in a statement that plasma infusions from young people provide “no proven clinical benefit” against normal aging,...
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Biggest ever map of human Alzheimer’s brain published
A study of the differences between healthy brains and those with Alzheimer’s Disease has produced largest dataset of its type ever. And the data, developed by a team of researchers led by Dr. Richard Unwin at The University of Manchester, is now freely available online for any scientist to use. The team included researchers from...
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Blood test detects Alzheimer’s damage before symptoms
A simple blood test reliably detects signs of brain damage in people on the path to developing Alzheimer’s disease—even before they show signs of confusion and memory loss, according to a new study from Washington University School of Medicine in St. Louis and the German Center for Neurodegenerative Diseases in Germany. Credit: CC0 Public Domain...
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Sleep deprivation accelerates Alzheimer’s brain damage
Poor sleep has long been linked with Alzheimer’s disease, but researchers have understood little about how sleep disruptions drive the disease. Credit: CC0 Public Domain Now, studying mice and people, researchers at Washington University School of Medicine in St. Louis have found that sleep deprivation increases levels of the key Alzheimer’s protein tau. And, in...
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Researchers discover new binding partner for amyloid precursor protein
An international team of researchers has discovered a new binding partner for amyloid precursor protein (APP)—a neurotransmitter called GABABR1a. In their paper published in the journal Science, the group describes their study of a non-pathogenic version of APP and what they found. Martin Korte with Technische Universität Braunschweig has written a Perspective piece on the...