In the brains of Alzheimer’s patients, many of the genes required to form new memories are shut down by a genetic blockade, contributing to the cognitive decline seen in those patients. MIT researchers have now shown that they can reverse that memory loss in mice by interfering with the enzyme that forms the blockade. The enzyme, known...
Tag: <span>Alzheimers</span>
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‘Ninja drug’ prevents Alzheimer’s by destroying harmful cells in the brain
Treatment stops the process that kills brain cells, protecting a patient’s memory Unlike other medications, the drug is cell-specific and does not have side effects The drug, known as PMN310 antibody, is effective as the brain can regenerate If successful in future trials, the medication could be available in 2025 Alzheimer’s affects around 5.5 million...
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Common blood pressure drug could halt progression of Alzheimer’s – and scientists need volunteers for a new £2m trial
Losartan could reduce brain shrinkage which occurs with incurable condition We already know people with high blood pressure have raised risk of Alzheimer’s But some are protected by the blood pressure drugs they take, past study found The group of inhibitors losartan belongs to cuts disease risk by up to 50% New study to test if drug helps...
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Using omega 3 fatty acids to treat Alzheimer’s and other diseases?
Understanding how dietary essential fatty acids work may lead to effective treatments for diseases and conditions such as stroke, Alzheimer’s disease, age-related macular degeneration, Parkinson’s disease and other retinal and neurodegenerative diseases. The key is to be able to intervene during the early stages of the disease. That is the conclusion of a Minireview by...
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HOW CLOSE ARE WE TO FINDING A TREATMENT FOR ALZHEIMER’S?
Countries around the world set a goal to find a treatment for Alzheimer’s disease by 2025. But that objective seems increasingly less attainable. There are about 30 drugs for Alzheimer’s disease now in Phase III clinical trials—the last set of experiments drug companies must run to prove their product is safe and effective before obtaining...
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Two new genes linked to Alzheimer’s risk
A team of researchers led by Cardiff University has identified two genes that influence a person’s risk of developing Alzheimer’s disease. The new finding, which builds on the team’s previous work of identifying 24 susceptibility genes, enables a better understanding of the mechanisms underlying the disease and offers further hope in developing new treatments. Dr...
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Peptide complex in the brain is responsible for Alzheimer’s disease
Members of the Faculty of Fundamental Medicine at the Lomonosov Moscow State University have determined the structure of a peptide complex formed in the brain at the early stages of Alzheimer’s disease. The research results will contribute to the rational design of compounds to block the progress of the disease. Alzheimer’s disease is associated with...
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New test paves way for potential treatments to target Alzheimer’s and other conditions
A simple methodology for capturing proteins implicated in the development of Alzheimer’s disease and other conditions has been developed by researchers at the University of Bradford and University of Dundee. The new methodology involves easily trapping proteins that bear a specific modification that can provide potential markers for conditions. The specific modification is based on...
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Missing link identified between immune cells and Alzheimer’s
By studying the effects of immune cells that surround blood vessels in the brain, Weill Cornell Medicine researchers have discovered a new pathway involving these cells that may contribute to the cause of Alzheimer’s disease. One of the hallmarks of Alzheimer’s disease is the accumulation of plaque deposits, or abnormal protein fragments, from a peptide...
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The Atomic Structure of a Key Alzheimer’s Protein Has Been Revealed
ENORMOUS POSSIBILITIES For the first time, scientists have revealed the chemical structure of one of the key markers of Alzheimer’s disease, capturing high-resolution images of the abnormal tau protein deposits suspected to be behind Alzheimer’s and other neurodegenerative conditions. The results will now give scientists an unprecedented glimpse at how these harmful deposits function at a molecular level,...