by UT Southwestern Medical Center Association of baseline acoustic (panel A) and lexical-semantic (panel B) scores with the 2-year change of CDR-SOB (higher value indicates greater disease progression). X-axis is the derived digital biomarker score. Y-axis is the change in CDR-SOB over 2 years. Higher baseline acoustic score and lower lexical-semantic scores were associated with greater...
by Brown University Credit: Pixabay/CC0 Public Domain While new drugs to treat Alzheimer’s disease tend to receive the most public attention, many well-researched ways to care for people with dementia don’t involve medication. A new evaluation compared the cost-effectiveness of four non-drug interventions to the usual care received by people with dementia and found that the...
WASHINGTON UNIVERSITY SCHOOL OF MEDICINE Nearly two dozen experimental therapies targeting the immune system are in clinical trials for Alzheimer’s disease, a reflection of the growing recognition that immune processes play a key role in driving the brain damage that leads to confusion, memory loss and other debilitating symptoms. Many of the immunity-focused Alzheimer’s drugs...
by American Chemical Society Graphical abstract. Credit: ACS Central Science (2023). DOI: 10.1021/acscentsci.2c01369 Certain diseases, including Alzheimer’s, are currently considered “undruggable” because traditional small molecule drugs can’t interfere with the proteins responsible for the illnesses. But a new technique that specifically targets and breaks apart certain proteins—rather than just interfering with them—may offer a pathway toward treatment....
by University of Delaware NAD+ and NADH concentrations in NEVs and change–change correlations with insulin signaling proteins. (a) Concentration of NAD+ after 6 weeks of oral nicotinamide riboside (NR) supplementation was significantly higher in NEVs when compared to placebo (n = 10, p = 0.0092, paired ttest), while NADH remained relatively unchanged (n = 22, p = 0.215,...
by King’s College London Flowchart of study design. CTL, cognitively normal controls; MCI, mild cognitive impairment; AD, Alzheimer’s disease; Aβ, β-amyloid; CSF, cerebrospinal fluid; A, amyloid pathology; T, tau pathology; N, neurodegeneration; PRS, polygenic risk score; MR, mendelian randomization. Credit: Alzheimer’s & Dementia (2023). DOI: 10.1002/alz.12961 A new study, published on Feb. 15 in Alzheimer’s & Dementia, analyzed...
UNIVERSITY OF CALIFORNIA – LOS ANGELES HEALTH SCIENCESPrintEmail App LOS ANGELES – Even the legendary filmmaker Orson Welles couldn’t have imagined such a plot twist. By showing Welles’s movie “Touch of Evil” to mice, Chinmay Purandare, PhD, and Prof. Mayank Mehta of UCLA have uncovered surprising and important new insights about how neurons form memories....
BAR-ILAN UNIVERSITY More than 55 million people worldwide were living with Alzheimer’s disease in 2020, according to Alzheimer’s Disease International. This figure is expected to almost double every 20 years, reaching 78 million in 2030 and 139 million in 2050. In 2021 the WHO Global Status Report estimated the annual worldwide cost of dementia as over...
Past studies have shown that intermittent fasting and living a physically active lifestyle may be able to slow age-related cognitive decline, which is a natural part of aging. New research has found that exercise, particularly short bursts of high intensity exercise can increase the amount of neuroprotective brain-derived neurotrophic factor (BDNF) in the body. The...
Over the last decade, you have probably heard about stem cell research on the news or online. You are probably wondering what exactly stem cells are and why they are such a popular subject for debate. In recent years, scientists and medical institutions have been studying many ways stem cell therapy can treat various diseases. Notably, in the field...
