by National Institutes of Health Left shows an image of the full-RPE-patch (2 x 4 mm). Each dot is an RPE cell with the borders stained green. Each patch contains approximately 75,000 RPE cells. Right image shows patch RPE cells at higher magnification. Credit: Kapil Bharti, Ph.D., NEI At the National Institutes of Health, a surgical...
by National Eye Institute A protein that normally deposits mineralized calcium in tooth enamel may also be responsible for calcium deposits in the back of the eye in people with dry age-related macular degeneration (AMD), according to a study from researchers at the National Eye Institute (NEI). This protein, amelotin, may turn out to be...
by Sanford Burnham Prebys Medical Discovery Institute Scientists at Sanford Burnham Prebys have identified the long-sought structure of an essential blood protein: vitronectin. Knowing the protein’s structure—an advance that enables rational drug design—could lead to medicines that kill multi-drug-resistant bacteria, halt cancer metastasis, treat age-related macular degeneration (AMD) and more. The study was published in...
By Lois Zoppi, BA Reviewed by Kate Anderton, B.Sc. (Editor) Researchers at the University of California, San Diego (UCSD) have uncovered a new genetic variant responsible for blood vessel dysregulation in the development of age-related macular degeneration (AMD), a retinal eye disease whose exact cause is yet to be discovered. The study was published in the journal Stem Cell Reports on 9th May 2019. What is Age-related Macular Degeneration (AMD)? Age-related macular...
A signaling pathway controlled by transforming growth factor beta (TGF-beta) could be involved in the progression of age-related macular degeneration (AMD). Researchers at the National Eye Institute (NEI), part of the National Institutes of Health, have found that interrupting TGF-beta signals to immune cells called microglia causes the cells to enter an activated, inflammatory state....
Calcified nodules in the retina are associated with progression to late stages of age-related macular degeneration (AMD). Experts from Queen’s University Belfast, working in partnership with the University of Alabama of Birmingham and in collaboration with UK material scientists and US clinical ophthalmology practices, made the ground-breaking discovery that the calcified nodules in the retina...
Jayakrishna Ambati, M.D., (left) and Nagaraj Kerur, Ph.D., have discovered a crucial trigger for macular degeneration, a condition which robs millions of their sight. The discovery may allow doctors to intervene early to halt the process. Credit: Josh Barney | UVA Health System In a major step forward in the battle against macular degeneration, the...
Two studies show cell-based treatment is safe in patients with dry macular degeneration, with one showing improved vision NEW ORLEANS, Nov. 14, 2017 /PRNewswire/ — Results from two early clinical trials show that it may be possible to use human embryonic stem cells as treatment for the dry form of macular degeneration, according to presentations given today at...
There’s evidence vitamins can slow the progression of existing macular degeneration. Vitamin and mineral supplements won’t prevent the development of age-related macular degeneration. But there is some evidence taking supplements containing vitamin C, vitamin E and zinc may slow the progression of age-related macular degeneration in those who already have it. This evidence comes from two major...
A supplement that combines antioxidants with zinc and copper is a relatively inexpensive and effective means of halting the progression of a certain type of degenerative eye disease, concludes research published online in the British Journal of Ophthalmology. Given the costs and side effects of the current range of drugs used to treat the ‘wet’ form...
