Tag: <span>amyloid</span>

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Groundbreaking study reveals what Alzheimer’s disease looks like inside the brain
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Groundbreaking study reveals what Alzheimer’s disease looks like inside the brain

By Chris Melore Research led by Dr. Rene Frank, University of Leeds Jul 11, 2024 Left, fluorescence image of amyloid in cryo-preserved post-mortem human brain. Middle, 3-dimensional molecular architecture of β-amyloid plaque. Right, in-tissue structure of tau filaments within post-mortem brain. (CREDIT: University of Leeds) LEEDS, United Kingdom — In a world-first achievement, scientists are...

Alzheimer’s disease and type 2 diabetes: Synthetic peptides may suppress formation of harmful amyloid aggregates
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Alzheimer’s disease and type 2 diabetes: Synthetic peptides may suppress formation of harmful amyloid aggregates

by Technical University Munich Proposed mechanism and hypothetical models of IAPP/ACM nanofiber co-assembly versus IAPP amyloid self-assembly. The lower part, IAPP self-assembly into toxic oligomers and amyloid fibrils. The upper part, in the presence of ACMs, IAPP monomers/prefibrillar species are redirected into initially amorphous and non-toxic hetero-assemblies, which convert into amyloid fibril-resembling but ThT-invisible and...

Amyloid deposits in eyes provide a peek at Alzheimer’s disease risk
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Amyloid deposits in eyes provide a peek at Alzheimer’s disease risk

by  University of California – San Diego Amyloid deposits tagged by curcumin fluoresce in a retinal scan. Credit: NeuroVision Amyloid plaques are protein deposits that collect between brain cells, hindering function and eventually leading to neuronal death. They are considered a hallmark of Alzheimer’s disease (AD), and the focus of multiple investigations designed to reduce or...

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A precise look at Alzheimer’s proteins

by  Environmental Molecular Sciences Laboratory A substance known as amyloid beta protein gets a lot of attention from scientists. Beta amyloid, as it’s also called, is a normal brain protein found in everyone, but for an unknown reason it gunks up in the brains of patients with Alzheimer’s disease, forming deposits that are the classic hallmark...

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Researchers answer decades-old question about protein found in Alzheimer’s brain plaques

Alzheimer’s-affected brains are riddled with so-called amyloid plaques: protein aggregates consisting mainly of amyloid-β. However, this amyloid-β is a fragment produced from a precursor protein whose normal function has remained enigmatic for decades. A team of scientists at VIB and KU Leuven led by professors Joris de Wit and Bart De Strooper has now uncovered that this amyloid precursor protein modulates neuronal signal...