by Free University of Brussels Liquid–liquid phase separation of G3BP1 is aggravated by R-rich C9orf72 DPRs. Credit: Proceedings of the National Academy of Sciences (2024). DOI: 10.1073/pnas.2402847121 Researchers from the Structural Biology Brussels group at Vrije Universiteit Brussel (VUB) have uncovered a significant mechanism that may contribute to amyotrophic lateral sclerosis (ALS), a disease that causes muscle weakness...
Tag: <span>Amyotrophic Lateral Sclerosis</span>
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What to know about amyotrophic lateral sclerosis MRI
MRI is a diagnostic test that doctors use to diagnose and track the progress of amyotrophic lateral sclerosis (ALS). ALS is a progressive disease that damages nerve cells in the brain and spinal cord. Over time, the condition causes a person to lose the ability to use their muscles, hindering their ability to walk, talk,...
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Rapid blood diagnostic test developed for amyotrophic lateral sclerosis
September 12, 2024 by Brain Chemistry Labs Neurally-derived extracellular vesicles extracted from a standard blood sample contain microRNA sequences used to diagnose ALS. Credit: Paul Cox.A highly accurate diagnostic blood test has been developed for amyotrophic lateral sclerosis (ALS), a progressive neurodegenerative disease that affects neurons in the brain and spinal cord. ALS leads to...
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New immune cell therapy benefits lab models of ALS and shows positive results in an individual with the disease
JULY 11, 2024 by Brian Burns, Massachusetts General Hospital An MRI with increased signal in the posterior part of the internal capsule which can be tracked to the motor cortex consistent with the diagnosis of ALS. Credit: Frank Gaillard/WikipediaImmune system dysregulation and elevated inflammation contribute to the development of the fatal neurodegenerative condition amyotrophic lateral...
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Extraocular muscles may provide key to defensive mechanisms against amyotrophic lateral sclerosis
by Umea University Credit: Pixabay/CC0 Public Domain A unique type of muscle fiber found in the extraocular muscles has been shown to be resistant against the disease amyotrophic lateral sclerosis (ALS), and has been shown to even increase in proportion to compensate when other types of muscle fibers decrease in proportion. This finding, by researchers at Umeå University...
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Parkinson’s disease drug ropinirole safely slows the progression of amyotrophic lateral sclerosis, finds clinical trial
by Cell Press Photo of iPSCs-derived Motor neurons derived from an ALS patient. Credit: Morimoto et al/Cell Stem Cell Amyotrophic lateral sclerosis (ALS), also known as Lou Gehrig’s disease, is a fatal motor neuron disease that causes people to gradually lose control of their muscles. There is no cure, and current treatments focus on reducing symptoms...
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A new immune pathway sheds light on amyotrophic lateral sclerosis
by Children’s Hospital Boston An MRI with increased signal in the posterior part of the internal capsule which can be tracked to the motor cortex consistent with the diagnosis of ALS. Credit: Frank Gaillard/Wikipedia While drugs are on the market to slow the progression of neurodegenerative diseases, there are still no cures. But researchers at Boston Children’s...
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Soft robotic wearable restores arm function for people with amyotrophic lateral sclerosis
by Harvard John A. Paulson School of Engineering and Applied Sciences This soft robotic wearable is capable of significantly assisting upper arm and shoulder movement in people with ALS. Credit: Walsh Lab, Harvard SEAS Some 30,000 people in the U.S. are affected by amyotrophic lateral sclerosis (ALS), also known as Lou Gehrig’s disease, a neurodegenerative...
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Study of skin biopsies offers potential as new diagnostic marker for amyotrophic lateral sclerosis (ALS)
by Miguel A. Rubio, Autonomous University of Barcelona Dermis cells, control vs ELA. Credit: UAB/Hospital del Mar Researchers of the Neuroplasticity and Regeneration Group of the Universitat Autònoma de Barcelona (UAB) and of the Functional Unit for Amyotrophic Lateral Sclerosis at the Hospital del Mar have identified the presence of an ALS biomarker in the...
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Researchers identify risk genes for amyotrophic lateral sclerosis
The largest analysis to date of genetic data in amyotrophic lateral sclerosis (ALS) – the muscle-crippling neurodegenerative disease that afflicted the late astrophysicist Stephen Hawking and cut short the career of iconic Yankee baseball slugger Lou Gehrig – has identified two previously unrecognized genetic risks that are significantly associated with the disease. In the...
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