Scientists have discovered how certain forms of motor neuron disease begin and progress at cellular and molecular levels, revealing potential new ways to slow down or even stop this process. The team are already working closely with pharmaceutical companies to use this knowledge to develop new treatments for motor neuron disease and other neurodegenerative conditions....
Tag: <span>amyotrophic lateral sclerosis (ALS)</span>
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Stem cell transplants may advance ALS treatment by repair of blood-spinal cord barrier
ALS mice improved with stem cell therapy; first step for science in finding better treatment Researchers at the University of South Florida show in a new study that bone marrow stem cell transplants helped improve motor functions and nervous system conditions in mice with the disease Amyotrophic Lateral Sclerosis (ALS) by repairing damage to the...
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New gene identified in Lou Gehrig’s disease
This stylistic diagram shows a gene in relation to the double helix structure of DNA and to a chromosome (right). The chromosome is X-shaped because it is dividing. Introns are regions often found in eukaryote genes that are removed in the …more For the first time, a variant in UBQLN4 gene has been associated with...
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The Endoplasmic Reticulum: Networking Inside the Cell
Like a successful business networker, a cell’s endoplasmic reticulum (ER) is the structure that reaches out—quite literally—to form connections with many different parts of a cell. In several important ways, the ER enables those other parts, or organelles, to do their jobs. Exciting new images of this key member of the cellular workforce may clarify...
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FDA approves drug to treat ALS
The U.S. Food and Drug Administration today approved Radicava (edaravone) to treat patients with amyotrophic lateral sclerosis (ALS), commonly referred to as Lou Gehrig’s disease. “After learning about the use of edaravone to treat ALS in Japan, we rapidly engaged with the drug developer about filing a marketing application in the United States,” said Eric...
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Scientists find evidence that ALS and SMA could be treated with a common drug
SMN protein (red) is necessary for the survival of spinal cord neurons (motor neurons) responsible for breathing and all movement. Harvard researchers have found a compound that stabilized this protein in mouse and human motor neurons. This …more Harvard Stem Cell Institute (HSCI) researchers have identified a compound that helps protect the cells destroyed by...
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Very low frequency electromagnetic field exposure linked to motor neurone disease
An MRI with increased signal in the posterior part of the internal capsule which can be tracked to the motor cortex consistent with the diagnosis of ALS. Workplace exposure to very low frequency electromagnetic fields may be linked to a doubling in risk of developing the most common form of motor neurone disease—amyotrophic lateral...
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