by National University of Singapore Extracellular vesicles deliver RIG-I agonists to fire up cancer cells and trigger immune attack. Credit: NUS Yong Loo Lin School of Medicine In the fight against cancer, the development of efficacious drugs is only half the battle; equally important is how drugs may be delivered efficiently and safely to the...
NATIONAL RESEARCH COUNCIL OF SCIENCE & TECHNOLOGY IMAGE: Schematic illustration of preferential immune responses during the cancer-activated DOX prodrug nanoparticle (CAP-NPS)-based chemotherapy: CAP-NPs exhibit selective tumor accumulation via enhanced permeability and retention (EPR) effect and cancer cell-specific activation by overexpressed cancer-associated cathepsin B. Consequently, CAP-NPs selectively initiate enhanced immunogenic cell death (ICD) in cancer cells...
