By Sally Robertson, B.Sc. Researchers in the U.S. have used a new web-based platform to help identify synergistic and antagonistic drug combinations and their underlying mechanisms of action in the context of coronavirus disease 2019 (COVID-19). The tool, called COVID-KOP, prioritized 73 combinations of 32 drugs as potential treatments for severe acute respiratory syndrome coronavirus...
by McMaster University McMaster University researchers have discovered a combination punch to treat drug-resistant infections that is showing promise based on testing in mice. Researchers found that a natural product called dephostatin is an effective partner for the antibiotic colistin in treating infections caused by the bacteria Salmonella. Colistin is considered a last-resort antibiotic for...
To more quickly identify drug combinations, such as those that might treat COVID-19, researchers have come up with an artificial intelligence platform called IDentif.AI. Traditionally, when dangerous new bacterial and viral infections emerge, the response is to develop a treatment that combines several different drugs. However, this process is laborious and time-consuming, with drug combinations...
Grouping 4 or 5 existing medications could help slow antibiotic-resistant bacteria UNIVERSITY OF CALIFORNIA – LOS ANGELES Scientists have traditionally believed that combining more than two drugs to fight harmful bacteria would yield diminishing returns. The prevailing theory is that that the incremental benefits of combining three or more drugs would be too small to...
