by Bridjes O’Neil, Saint Louis University Credit: Unsplash/CC0 Public DomainResearchers at Saint Louis University School of Medicine say diagnostic delays frequently occur in patients with undiagnosed head and neck cancer (HNC) and are calling for improved dissemination of current clinical practice guidelines in a new paper published Aug. 24 in JAMA Otolaryngology—Head & Neck Surgery....
by Krista Conger, Stanford University Medical Center Landmarking analysis to evaluate the impact of antimicrobial exposure on survival over time on N = 772 independent patients. Data were presented as the hazard ratios ± 95% confidence intervals that reflect the risk of ongoing antimicrobial exposure at yearly intervals post-diagnosis and are plotted for the cumulative exposure definitions of total and...
by Cold Spring Harbor Laboratory The chemical structure of the new antibiotic was designed by Moses and synthetically assembled by his lab. Dr. Thomas Fallon, Moses’ collaborator at the University of Newcastle, Australia, provided the shape-shifting bullvalene core. Moses says one commenter called the study “probably the ‘coolest’ and most complex natural product derivative paper I’ve...
Liam Drew In the presence of antidepressants, the Gram-negative bacteria, E. coli, can fend off antibiotics. Credit: Steve Gschmeissner/Science Photo Library The emergence of disease-causing bacteria that are resistant to antibiotics is often attributed to the overuse of antibiotics in people and livestock. But researchers have homed in on another potential driver of resistance: antidepressants....
By Ben Coxworth January 26, 2023 Peptides in the spray kill bacteria (pictured) by damaging their protective outer membranes Depositphotos It’s always good if the use of antibiotics can be avoided, to keep harmful bacteria from developing a resistance to them. A new wound-treatment spray could help, as it kills bacteria using peptides that occur...
by British Medical Journal Credit: Pixabay/CC0 Public Domain Frequent use of antibiotics may heighten the risk of inflammatory bowel disease—Crohn’s disease and ulcerative colitis—among adults over 40, suggests research published online in the journal Gut. The risk seems to be cumulative and greatest 1-2 years after use and for those antibiotics targeting gut infections, the findings indicate. Mounting...
HOKKAIDO UNIVERSITY IMAGE: THE SPHAERIMICIN ANALOGS (SPMS) INHIBIT THE ACTIVITY OF MRAY, AND HENCE THE REPLICATION OF BACTERIA, WITH DIFFERENT DEGREES OF EFFECTIVENESS. THE POTENCY OF THE ANALOG INCREASES AS THE IC50 DECREASES (TAKESHI NAKAYA, ET AL. NATURE COMMUNICATIONS. DECEMBER 20, 2022). CREDIT: (TAKESHI NAKAYA, ET AL. NATURE COMMUNICATIONS. DECEMBER 20, 2022) Researchers have designed...
by Ochsner Health System Credit: Unsplash/CC0 Public Domain A new study led by Ochsner infectious diseases clinical pharmacist Kevin Lin, PharmD, was recently published in PLoS One, suggesting that oral cephalosporins are as safe and effective as the standard of care fluoroquinolones (FQs) for the treatment of acute kidney infections. Cephalosporins belong to a family of...
MCMASTER UNIVERSITY IMAGE: SCIENTISTS TEST ‘SMART’ RED BLOOD CELLS TO DELIVER ANTIBIOTICS THAT TARGET SPECIFIC BACTERIA CREDIT: ELLA MARUSHCHENKO Physicists at McMaster University have identified a natural delivery system which can safely carry potent antibiotics throughout the body to selectively attack and kill bacteria by using red blood cells as a vehicle. The platform, described...
FUNDAÇÃO DE AMPARO À PESQUISA DO ESTADO DE SÃO PAULO IMAGE: IT CAN BE USED TO STUDY THE RESISTANCE PROFILE OF PNEUMOCOCCUS EVEN IN THE ABSENCE OF THE ISOLATED STRAINS (PNEUMOCOCCI OBSERVED IN THE MICROSCOPE) CREDIT: IVANA CAMPOS A study published in the journal PLOS ONE could one day help health workers determine whether bacteria of the species Streptococcus pneumoniae,...
