Randy Dotinga December 07, 2024 01 SAN DIEGO — Compared with clinical trials, a real-world retrospective analysis has linked the bispecific antibodies epcoritamab (Epkinly) and glofitamab (Columvi) to somewhat poorer outcomes in relapsed or refractory large B-cell lymphoma (LBCL). In a presentation here at the American Society of Hematology (ASH) 2024 Annual Meeting, researchers reported that of 172 patients treated with the...
Tag: <span>antibodies</span>
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Next-gen cell-penetrating antibodies for tumor targeting and RAD51 inhibition
“Overall, the data presented in this study affirm that humanizing 3E10 preserves its crucial biological properties essential for therapeutic efficacy.” Impact Journals LLC image: Figure 1: 3E10 humanization and heavy and light chain variant screening. (A) Diagram of the 3E10 antibody engineering process. The original murine wild-type 3E10 was modified to contain a human IgG1 Fc...
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Tumor-specific antibodies able to detect melanoma in its earliest stages, new study shows
September 25, 2024 by European Academy of Dermatology and Venereology Innovative research has unveiled promising advancements in melanoma detection, which could significantly enhance diagnosis and prognosis by identifying the disease at its earliest, most treatable stages. This new method, presented today at the European Academy of Dermatology and Venereology (EADV) Congress 2024, uses tumor-specific profiling...
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Tiny antibodies to fight the dangerous effects of opioids
UNIGE researchers have discovered molecules capable of limiting the side effects of opioids by blocking the receptor responsible for their action. Peer-Reviewed Publication Université de Genève image: NbE (red) binds the specific receptor responsible for opioid action (blue) and blocks off other small molecules (white/yellow/red). Credit: © UNIGE Opioid drugs are highly effective at relieving...
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HIV antibodies protect animals in proof-of-concept study
by National Institutes of Health Transmission electron micrograph of HIV-1 virus particles (red) budding and replicating from a segment of a chronically infected H9 cell (blue). Particles are in various stages of maturity; arc/semi-circles are immature particles that have started to form but are still part of the cell. Immature particles slowly change morphology into mat....
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Scientists discover antibodies capable of stopping several coronaviruses, potentially preventing future outbreaks
FILE – This undated electron microscope image made available by the U.S. National Institutes of Health in February 2020 shows the Novel Coronavirus SARS-CoV-2, orange, emerging from the surface of cells, green, cultured in the lab. (NIAID-RML via AP) Noushin Ziafati CTVNews.ca Writer-Producer Follow | Contact Published July 30, 2023 8:02 a.m. MST Share Newly discovered antibodies...
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Chemists’ technique reveals whether antibodies neutralize SARS-CoV-2
by Anne Trafton, Massachusetts Institute of Technology Graphical abstract. Credit: ACS Central Science (2023). DOI: 10.1021/acscentsci.2c01471 Antibodies that can disarm a virus, known as neutralizing antibodies, are key to the body’s ability to fight off infection. MIT chemists have come up with a new way to identify these neutralizing antibodies in a blood sample, by analyzing how antibodies...
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The longer the bootcamp, the better the antibodies
LA JOLLA INSTITUTE FOR IMMUNOLOGY IMAGE: LEFT TO RIGHT: LJI PROFESSOR SHANE CROTTY, PH.D., AND LJI POSTDOCTORAL FELLOW HARRY SUTTON, PH.D. CREDIT: MATT ELLENBOGEN, LJI LA JOLLA, CA—Researchers at La Jolla Institute for Immunology (LJI) have discovered how the immune system can transform into an antibody-making machine capable of neutralizing one of the most elusive...
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Researchers have identified antibodies that may make coronavirus vaccines unnecessary
TEL-AVIV UNIVERSITY IMAGE: DR. NATALIA FREUND CREDIT: TEL AVIV UNIVERSITY Tel Aviv University researchers have isolated two antibodies that neutralize all known strains of COVID-19 – including Omicron – with up to 95% efficiency. The researchers: Targeted treatment with antibodies and their delivery to the body in high concentrations may serve as an effective substitute...
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Scientists zero in on antibodies capable of neutralizing HIV
by Delthia Ricks, Medical Xpress Expression and purification of VRC07 IgG subclasses. (A) Schematic representations of the adeno-associated virus (AAV) vectors used for in vivo expression of VRC07 IgG subclasses; the vectors include inverted terminal repeats (ITR), CASI promoter, various VRC07 IgG heavy chains (HC) linked to the VRC07 kappa light chain separated by a...