by Jeff Hansen, University of Alabama at Birmingham Isolation of SARS-CoV-2 S2-specific human monoclonal antibodies (hmAbs). (A) Schematic representation of the S2-STBL and S1/S2 chimera proteins used as baits for ELISA and flow cytometry. (B) Human plasma from either convalescent or healthy subjects was diluted 1:1000 in PBS and tested in duplicate in an ELISA...
by Rockefeller University HIV infecting a human cell. Credit: NIH Antiretroviral therapy has made HIV a manageable condition, but it does not eliminate the virus from the body—and most regimens are expensive and require a pill every day, for the rest of the patient’s life. Now, findings from a clinical trial led by Rockefeller University...
by Focused Ultrasound Foundation MR images showing reduction in size of metastatic tumors after focused-ultrasound delivery of antibody therapy through blood-brain barrier. Credit: Sunnybrook Health Sciences Centre In a first-in-world clinical trial, researchers at Sunnybrook Health Sciences Centre in Toronto, Canada, have demonstrated that magnetic resonance (MR)-guided focused ultrasound can be used to safely deliver...
NYU LANGONE HEALTH / NYU GROSSMAN SCHOOL OF MEDICINE Researchers rescued mice from early death caused by a muscle-weakening disease, not by correcting the flawed gene that causes it, but instead by targeting another protein in the same signaling pathway. Led by NYU Grossman School of Medicine researchers, a new study found that an antibody treatment not...
by Eileen Hoftyzer, University of Toronto Professors Stéphane Angers and Sachdev Sidhu pictured in the Donnelly Centre before the COVID-19 pandemic. Credit: University of Toronto The life-saving diabetic medication insulin, developed at the University of Toronto 100 years ago, was the first biologic therapy—a protein to treat disease. A century later, a new biologic therapy also...
Kalipada Pahan, Ph.D. Certain cancer cells stave off their death with help from a particular molecule in a protein involved in the body’s immune system response, a research team at Rush University Medical Center has found. The researchers also have shown that neutralizing the molecule with a customized antibody therapy they developed can kill...
