by Sarah Avery, Duke University Graphical abstract. Credit: Cell (2024). DOI: 10.1016/j.cell.2023.12.002The path to a successful HIV vaccine depends on a critical first step—activating specific immune cells that induce broadly neutralizing antibodies. Reporting Jan. 4 in the journal Cell, a research team led by the Duke Human Vaccine Institute has achieved that requisite initial step in...
by Felicia Lindberg, Karolinska Institutet Credit: Pixabay/CC0 Public Domain Researchers at Karolinska Institutet and Danderyd Hospital have followed recipients of the new updated COVID-19 vaccine and analyzed the antibody response to different SARS-CoV-2 variants. The results show a surprisingly strong response to the now dominant and highly mutated omicron variants. The ongoing COMMUNITY study, which was...
by Public Library of Science Humans mount convergent H1N1-H3N2 neutralizing antibody responses to influenza virus. Panels are derived from structures reported by Simmons et al., (PDB 7TRH, 7RRI and 3UBE by Xu et al., for the model of receptor engagement). Credit: Kevin McCarthy (CC-BY 4.0, creativecommons.org/licenses/by/4.0/) Researchers have identified a previously unrecognized class of antibodies—immune system...
by University of Montreal CD47 interacts in cis with SLAMF7 on tumor cells. a, Binding of CD47-Fc (red line) to WT or Sirpa−/− BMDMs assayed by flow cytometry. Filled curves, Ctrl Fc. b, Mass spectrometry analysis of Flag mAb immunoprecipitates from L1210 derivatives expressing a Flag-tagged variant of mCD47 showing various potentially associated proteins. c, Co-IP...
by Duke University Credit: Unsplash/CC0 Public Domain For too long, cancer treatment has been a double-edged sword—the very treatments designed to kill cancer cells often wrought havoc on healthy ones too. But a new study published online Oct. 30 in Immunity unveils an approach to cancer treatment that researchers describe as more precise, long-lasting, and less...
by Translational Genomics Research Institute SIWA318H treatment depletes p16INK4a positive cells and reduces αSMA expression in PSN1 xenograft tumors. (A) Quantification of the number of p16INK4a positive cells in isotype control antibody treated and SIWA318H treated tumors. (B) Quantification of αSMA positive areas in isotype control antibody treated and SIWA318H treated tumors. (C) A representative image...
by Weill Cornell Medical College Zika virus particles (red) shown in African green monkey kidney cells. Credit: NIAID An unusual type of antibody that even at miniscule levels neutralizes the Zika virus and renders the virus infection undetectable in preclinical models has been identified by a team led by Weill Cornell Medicine, New York-Presbyterian and...
by Wiley Credit: Unsplash/CC0 Public Domain Over the past two decades, numerous complex cancer therapies called antibody drug conjugates (ADCs) have been tested in clinical trials and approved for use in patients. Investigators recently performed a comprehensive analysis of multiple scientific databases to outline the potential toxicities associated with these medications. Their findings are published...
BY KORIN MILLER PUBLISHED: SEP 6, 2022 COVID-19 vaccines have been effective at keeping people from getting severely ill and dying from the virus, but they’ve required different boosters to try to keep on top of all of the coronavirus variants that have popped up. Now, researchers have discovered an antibody that neutralizes all known COVID-19...
by Children’s Hospital Boston Credit: Unsplash/CC0 Public Domain As SARS-CoV-2 has evolved and mutated, therapeutic antibodies that worked early in the pandemic have become less effective, and newer variants, especially omicron, have developed ways to evade the antibodies we make in response to vaccines. A new, broadly neutralizing antibody developed at Boston Children’s Hospital could potentially...
