by Wiley Credit: Unsplash/CC0 Public Domain Over the past two decades, numerous complex cancer therapies called antibody drug conjugates (ADCs) have been tested in clinical trials and approved for use in patients. Investigators recently performed a comprehensive analysis of multiple scientific databases to outline the potential toxicities associated with these medications. Their findings are published...
BY KORIN MILLER PUBLISHED: SEP 6, 2022 COVID-19 vaccines have been effective at keeping people from getting severely ill and dying from the virus, but they’ve required different boosters to try to keep on top of all of the coronavirus variants that have popped up. Now, researchers have discovered an antibody that neutralizes all known COVID-19...
by Children’s Hospital Boston Credit: Unsplash/CC0 Public Domain As SARS-CoV-2 has evolved and mutated, therapeutic antibodies that worked early in the pandemic have become less effective, and newer variants, especially omicron, have developed ways to evade the antibodies we make in response to vaccines. A new, broadly neutralizing antibody developed at Boston Children’s Hospital could potentially...
by The Scripps Research Institute Macaque antibodies were shown to induce a much broader immune response against SARS-related viruses, including emerging variants, which could help with the development of new human vaccines. Human CC12.1 (purple) and macaque K398.22 (orange) antibodies bind to different regions of the receptor binding domain (RBD) on SARS-CoV-2 (white). Credit: Scripps Research...
by University of Tokyo Researchers report a new, minimally invasive, antibody-based detection method for SARS-CoV-2 that could lead to the blood sample-free detection of many diseases. Credit: Institute of Industrial Science, The University of Tokyo Despite significant and stunning advances in vaccine technology, the COVID-19 global pandemic is not over. A key challenge in limiting the...
by University of California – San Diego Credit: Nano Letters (2022). DOI: 10.1021/acs.nanolett.2c01328 A new combination therapy to combat cancer could one day consist of a plant virus and an antibody that activates the immune system’s “natural killer” cells, shows a study by researchers at the University of California San Diego. In mouse models of colon cancer,...
by US Army Medical Research Institute of Infectious Diseases Hantavirus particles display a characteristic square surface “lattice” made up of building blocks that contain the envelope glycoproteins Gn and Gc. These glycoproteins, which are the sole targets of neutralizing antibodies, control the virus’s ability to enter cells. Figure shows a schematic representation of the glycoproteins...
by Osaka University Anti-RGMa antibody treatment ameliorates NMO pathophysiology. Credit: Takahide Itokazu Autoimmune diseases are the molecular equivalent of “friendly fire”: The body attacks itself instead of harmful invaders. Now, researchers from Japan have found that interrupting the complex interplay between different immune cell types can help prevent the damage that this friendly fire causes...
by Weill Cornell Medical College Credit: Blausen Medical, CC BY-SA 4.0 The master regulator behind the development of antibody-producing cells has been identified in a study by investigators at Weill Cornell Medicine. The findings provide new insight into the inner workings of the immune system and may help understand how tissues develop and how certain...
by Marla Paul, Northwestern University Elizabeth McNally, MD, PhD, director of the Center for Genetic Medicine and the Elizabeth J. Ward Professor of Genetic Medicine, was the senior author of the study. Credit: Northwestern University Northwestern Medicine scientists have developed an antibody that they believe can be used to treat muscular dystrophy, findings that were published...
