The metabolic product of an anticancer drug demonstrates potential activity in neurons derived from Parkinson’s patients and a synergistic action, together with the original drug, in prostate cancer cellsPeer-Reviewed Publication SPANISH NATIONAL RESEARCH COUNCIL (CSIC) L’Hospitalet de Llobregat, February 8th, 2024. Once they enter the body, drugs, apart from carrying out their therapeutic function, are...
Tag: <span>Anticancer drug</span>
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Finding the optimal combination of anticancer drug administration for the conditioning of cord blood transplantation
by University of Tsukuba Credit: Unsplash/CC0 Public DomainAllogeneic hematopoietic stem-cell transplantation (allo-HSCT) can cure hematopoietic diseases, such as acute myeloid leukemia. Cord blood transplantation (CBT), which accounts for more than one-third of allo-HSCTs in Japan, uses hematopoietic stem cells contained in the blood in the umbilical cord and placenta. Moreover, it is a valuable option for...
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Discovery unveils promising anticancer drug targeting KRAS protein
by Virginia Commonwealth University KRB-456 inhibits the growth in vivo of orthotopic mt KRAS tumors derived from pancreatic cancer patients. Tumor biopsies from pancreatic cancer patient G160 were prepared and implanted orthotopically into NSG mice as described in Methods. On day 20 after implantation, mice were treated i.p. daily for 30 days with vehicle or 5mpk...
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Anticancer drugs: a new hope for sepsis treatment
INSTITUTO GULBENKIAN DE CIENCIA The body’s extreme response to infection, a condition called sepsis, kills 11 million people every year. This is because to survive a serious infection it is not enough to get rid of the infectious agent, which is currently done with relative effectiveness; it is also necessary to limit the damage these and the immune response cause on the organs....
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Osmotic pressure and viscosity: Anticancer drug efficacy and restricting tumors using LDDS
by Tohoku University Figure 1. The improvement of drug delivery of anticancer drugs by expansion of lymphatic sinus with high osmotic and high viscosity solvents from A to H. Credit: Tohoku University Chemotherapy is known for its painful side-effects. It also has limitations when the cancer has metastasized to the lymph nodes. The lymphatic drug...