by Meike Drießen, Ruhr-Universitaet-Bochum Proposed mechanism of the reduction of the PtIV prodrug Pt1 with the pentacoordinated sonosensitizer using DFT calculations. (A) Energy profile diagram of the reduction, indicative that the reaction is thermodynamically unfavored. (B) Proposed reduction mechanism . Credit: Angewandte Chemie International Edition (2023). DOI: 10.1002/anie.202301074 Chemotherapy treatments produce strong side effects. A new agent that accumulates...
