TOKYO UNIVERSITY OF SCIENCE IMAGE: INTRANASAL ADMINISTRATION OF PAS-CPP-GLP-2 RESULTS IN ITS DELIVERY TO THE BRAIN VIA TRIGEMINAL AXONS OF THE TRIGEMINAL NERVES. THEREFORE, IT IS THOUGHT TO CONSTITUTE A NERVE-ASSOCIATED TRANSCELLULAR PATHWAY FOR DRUG DELIVERY. CREDIT: PROF. CHIKAMASA YAMASHITA FROM TOKYO UNIVERSITY OF SCIENCE Intranasal (in.) administration has been garnering increasing popularity as a...
by Northwestern University 3-D model of Ketamine. Credit: Wikipedia Ketamine is the speedster of antidepressants, working within hours compared to more common antidepressants that can take several weeks. But ketamine can only be given for a limited amount of time because of its many side effects. Now, a new Northwestern Medicine study identifies for the...
by Weizmann Institute of Science How ketamine works: A schematic representation of ketamine’s newly discovered and previously known mechanisms of action. Ketamine molecules directly inhibit a receptor for the neurotransmitter glutamate (top left), generating a cascade of biochemical reactions that increases the expression of potassium channels (KCNQ) in neurons belonging to the glutamate network in...
Antidepressant withdrawal may have associations with antidepressant discontinuation syndrome. Therefore, under the advice of a doctor, a person should reduce or taper their medication gradually. Symptoms of antidepressant withdrawal can include flu-like symptoms and occur within 2–4 days after drug stoppage. Ceasing antidepressant medications without slowly reducingTrusted Source them can lead to a number of symptoms, most of which...
by George Mason University Credit: CC0 Public Domain Although antidepressants are one of the most frequently taken medications in the United States (11% of the population takes antidepressants) 60% of depressed patients do not benefit from their first antidepressant. The sales of antidepressants exceed several billion dollars annually. According to a new study published today from...
Vancouver, Canada (26 August 2021) In June 2020, The TOGETHER Trial was established as an adaptive platform randomised clinical trial to test a range of potential treatments for COVID-19 that might be suitable for clinical use in a community setting in Brazil and other low- and middle-income countries. The trial specifically tested each treatment’s potential to prevent clinical worsening of COVID-19 requiring...
UNIVERSITY OF CALIFORNIA – LOS ANGELES HEALTH SCIENCES IMAGE: SHIRLEY XI WANG, LILI YANG AND RYAN YU-CHEN WANG FOUND THAT MICE BECAME MORE CAPABLE OF FIGHTING MELANOMA AND COLON TUMORS WHEN TREATED WITH MAOIS. CREDIT: UCLA BROAD STEM CELL RESEARCH CENTER A class of drug called monoamine oxidase inhibitors is commonly prescribed to treat depression; the medications...
Technology Org Science and technology news Posted Today In a new study published in the journal JAMA Psychiatry, researchers at Karolinska Institutet have studied CYP2C19 and CYP2D6 genes impact on treatment with antidepressants and antipsychotic drugs. The study shows that control of the patient’s genotype can be used to individualize the drug treatment and lead to...
by KU Leuven New research has shown that the antidepressant sertraline inhibits the growth of cancer cells. It acts on a metabolic addiction that allows different types of cancer to grow. This is shown by a study on cell cultures and lab animals performed by various research labs of KU Leuven. Their findings were published in Molecular Cancer Therapeutics, a journal...
UNIVERSITY OF CALIFORNIA – IRVINE Irvine, Calif. – September 30, 2020 – In a new study, published in Current Biology, researchers from the University of California, Irvine School of Medicine reveal how subanesthetic ketamine, which is used for pain management and as an antidepressant in humans, is effective in treating adult amblyopia, a brain disorder commonly known as...
