Highlights CbpS436A increases the reprogramming efficiency of i-pericytes to NPCs in culture CbpS436A increases the number of locally derived NPCs from i-pericyte in vivo CbpS436A shows impaired vascular remodeling and functional recovery after stroke Summary Epigenetic modifications have emerged as attractive molecular substrates that integrate extrinsic changes into the determination of cell identity. Since stroke-related brain damage...