Tag: <span>Apolipoprotein E</span>

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Apolipoprotein E destabilizes heterochromatin and drives senescence
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Apolipoprotein E destabilizes heterochromatin and drives senescence

by Zhang Nannan, Chinese Academy of Sciences Nuclear-localized APOE promotes human stem cell senescence. Credit: Liu Guanghui’s lab Prof. Liu Guanghui and his colleagues from the Institute of Zoology and the Beijing Institute of Genomics of the Chinese Academy of Sciences have collaborated to find that Apolipoprotein E (APOE) destabilizes heterochromatin and drives senescence in...

Study now links non-mutated Apolipoprotein E to dementia in the aging brain
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Study now links non-mutated Apolipoprotein E to dementia in the aging brain

by Elsevier Immunofluorescence microscopy showing a single neuritic amyloid plaque with the localization of Apolipoprotein E (ApoE) (green; A), complement protein C4 (red; B), and Tau (white; C) proteins in amygdala. This is from an individual with the APOE ε3/3 genotype (Case 1068). In the depicted plaque-like structure, the ApoE signal is strongest in the...