by University of Virginia Atherosclerosis is a condition affecting the cardiovascular system. If atherosclerosis occurs in the coronary arteries (which supply the heart) the result may be angina pectoris, or in worse cases a heart attack. Credit: Wikipedia/CC BY 3.0University of Virginia School of Medicine scientists have found important answers about strokes, heart attacks, and...
by Linköping University Credit: Unsplash/CC0 Public DomainMen who were physically fit when they were young had a lower risk of atherosclerosis almost 40 years later, according to a study led by researchers at Linköping University, Sweden. The findings, published in the British Journal of Sports Medicine, suggest that atherosclerosis is one of the mechanisms behind the...
by Ludwig Maximilian University of Munich Pathway synopsis (I.) Sterile inflammation triggers the activation of a subset of cDCs, which respond by releasing CCL17. (II.) In turn, CCL17 binds to CCR8 on cDCs (autocrine) and on CD4+ T cells (paracrine) to stimulate an upregulation of CCL3 expression and release. (III.) Subsequently, CCL3 interacts with CCR1 on...
by Cactus Communications Joinpoint regression analysis of global PAD prevalence (A), incidence (B), mortality rate (C), and DALYs (D) in adults ≥20 years of age from 1990 to 2019. * P <0.05. APC: Annual percentage change; DALYs: Disability-adjusted life years; PAD: Peripheral arterial disease. Credit: Chinese Medical Journal (2023). DOI: 10.1097/CM9.0000000000002839. Cardiovascular diseases are a...
by Thamarasee Jeewandara , Medical Xpress A multiplexed diagnostic tool for detecting intraplaque and urinary MDA. We design a multiplexed diagnostic tool that includes two functions (photoacoustic imaging and urinalysis), for assessing intraplaque and urinary MDA and reliably assessing intraplaque and systematic oxidative stress in atherosclerosis. Credit: Science Advances, DOI: 10.1126/sciadv.adh1037Oxidative stress is fundamental to...
by Medical University of Vienna Credit: Kateryna Kon/Shutterstock Heart attacks and strokes arising from atherosclerosis, which is driven by the accumulation of lipids in the inner linings of arteries, are responsible for about one third of deaths worldwide. Accordingly, atherosclerosis is the focus of intense research aimed at the development of novel effective treatments. A team of researchers from MedUni...
by Yale School of Medicine In a new study, researchers including Yale School of Medicine’s Michael Simons, MD, identify the molecular underpinnings of persistent endothelial-to-mesenchymal transition (EndMT), an important process related to vascular inflammation in diseases including pulmonary hypertension. Researchers found atypical acetate production from glucose triggered metabolic modulation of the endothelium activated TGF-β signaling, triggering a...
by American Society for Biochemistry and Molecular Biology Enpp2 gene expression and autotaxin protein levels in jejunum. A. Enpp2 gene expression after feeding a chow diet (Chow) or Western diet (WD) for two weeks. Female Enpp2fl/fl/Ldlr-/- (Cont.) mice 3.1 ± 0.4 months of age (n = 5 mice per group) and female Enpp2fl/fl/Ldlr-/-/VilCre (iKO) mice 3.9 ±...
AMERICAN SOCIETY FOR BIOCHEMISTRY AND MOLECULAR BIOLOGY IMAGE: MICROSCOPY IMAGE OF A MOUSE AORTA WITH ATHEROSCLEROTIC LESIONS. PLAQUES ARE SHOWN IN RED. CREDIT: SRINIVASA REDDY In a recent study, researchers determined that derivatives of natural emulsifiers such as phospholipids found in high-fat, high-cholesterol diets can promote atherosclerosis via gut bacteria interactions with the immune system. This...
Carolyn Crist February 23, 2023 Irregular sleep — such as inconsistent sleep duration or sleep timing — may increase the risk of developing atherosclerosis among adults older than age 45, a new report suggests. In particular, variation in sleep duration of more than 2 hours per night in the same week was tied to higher rates of...
