Reviewed by Emily Henderson, B.Sc.Dec 12 2022 Patients with moderate to severe atopic dermatitis who participated in a clinical trial of rocatinlimab-;a novel, patient-tailored monoclonal antibody therapy-;showed promising results both while taking the drug and up to 20 weeks after the therapy was stopped, Mount Sinai researchers reported in The Lancet. The researchers said the results indicate...
Tag: <span>atopic dermatitis</span>
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A serendipitous finding lends new insight into how atopic dermatitis develops
UNIVERSITY OF PENNSYLVANIA Atopic dermatitis, a common skin condition affecting both children and adults, is often thought of as an inflammatory disease that arises from a breakdown in the barrier function of the skin. Now a new study pinpoints a cascade of inflammatory signaling that precedes the appearance of skin ulcers, shedding light on the...
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Upadacitinib in moderate to severe atopic dermatitis: high doses produce added benefit for adults
INSTITUTE FOR QUALITY AND EFFICIENCY IN HEALTH CARE Upadacinib is a new drug for the treatment of adults and adolescents aged 12 years and older with moderate to severe atopic dermatitis who are candidates for systemic therapy. In an early benefit assessment, the German Institute for Quality and Efficiency in Health Care (IQWiG) has now...
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New cell type in human skin discovered to contribute to inflammatory skin diseases like atopic dermatitis and psoriasis
AGENCY FOR SCIENCE, TECHNOLOGY AND RESEARCH (A*STAR) SINGAPORE IMAGE: IMMUNOFLUORESCENCE LABELING OF HEALTHY AND PSORIATIC PATIENT SKIN. DOTTED LINE SHOWS THE DERMAL–EPIDERMAL JUNCTION. HLA-DR: GREEN, GLUT3 (SLC2A3): RED, AND DAPI: BLUE. SCALE BAR = 100 ΜM (LOW MAGNIFICATION) AND 10 ΜM (HIGH MAGNIFICATION). CREDIT: PLEASE CREDIT IMAGE TO A*STAR SINGAPORE IMMUNOLOGY NETWORK (SIGN) AND SKIN...
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Five Do’s and Five Don’ts for Managing Atopic Dermatitis
Topical corticosteroids should be applied just once daily to treat atopic dermatitis (AD), and prescribing oral antihistamines should be phased out, dermatologists recommend in a new review. The authors also encourage four other treatment practices for AD and dissuade use of well-known interventions that have shown no clinical benefit. Dr Hywel Williams These recommendations give patients “safer and more effective approaches...
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Upadacitinib Appears Effective Against Atopic Dermatitis in Teens and Adults
By Marilynn Larkin June 04, 2021 NEW YORK (Reuters Health) – Two-phase 3, placebo-controlled studies suggest the oral Janus kinase (JAK) inhibitor upadacitinib is effective for moderate-to-severe atopic dermatitis (AD), both alone and with topical corticosteroids. “The results are highly robust and consistent among studies with really high efficacy and clearance rates that we have not seen...
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Children with worse atopic dermatitis more likely to have learning disabilities
(HealthDay)—Worse atopic dermatitis (AD) severity is associated with increased odds of learning disorders in pediatric patients, according to a study published online April 14 in JAMA Dermatology. Joy Wan, M.D., from the University of Pennsylvania Perelman School of Medicine in Philadelphia, and colleagues used data from 2,074 participants (aged 2 to 17 years) in the Pediatric...
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Discovery pinpoints new therapeutic target for atopic dermatitis
by Thomas Deane, Trinity College Dublin Credit: CC0 Public Domain Researchers from Trinity have discovered a key mechanism underlying bacterial skin colonisation in atopic dermatitis, which affects millions around the globe. Atopic dermatitis (AD, also called commonly eczema) is the most common chronic inflammatory skin disorder in children, affecting 15-20% of people in childhood. During disease flares, patients experience...
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New efficacies of Ganoderma lucidum: Treatment of skin conditions like atopic dermatitis
NATIONAL RESEARCH COUNCIL OF SCIENCE & TECHNOLOGY IMAGE: ANTI-INFLAMMATORY ACTIVE MECHANISM IN SKIN CELLS. Ganoderma lucidum, known as Yeongji mushroom in Korea, is called a modern-day elixir plant and has long been used medicinally in China, Japan and Korea. Ganoderic acid, an active ingredient found in the mushroom, is known for its excellence in enhancing the immune...
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A New Era in the Treatment of Atopic Dermatitis
M. Le Bwohl DISCLOSURES The British Journal of Dermatology. 2019;181(4):658 We are on the verge of major breakthroughs in the treatment of atopic dermatitis. We already have many topical therapies, and newer ones in the form of aryl hydrocarbon receptor modulating agents and topical Janus kinase (JAK) inhibitors are on the way.[1,2] Injectable biologic therapies...