by Ellen Goldbaum, University at Buffalo Fig. 1: ASH1L expression and H3K4me3 level are significantly decreased in PFC of postmortem ASD patients, which is replicated by knockdown of Ash1L in PFC of young mice. a Quantitative PCR data showing ASH1L mRNA levels in postmortem PFC tissues from control humans vs. idiopathic ASD patients. n = 12 humans (10 M,2 F)/group,...
by RIKEN H3K9 methylation levels in the cerebellum were lower in the Suv39h2-deficient mice than in control mice controls. Credit: RIKEN New research from the RIKEN Center for Brain Science (CBS) in Japan shows that a deficit in histone methylation could lead to the development of autism spectrum disorders (ASD). A human variant of the SUV39H2...
Autism spectrum disorders (ASDs) are neurodevelopmental disorders characterized by communication disorders, altered social interactions and sensory and behavioral abnormalities. Research in genetics and brain imaging suggests that abnormalities in the development of the brain concerning, in particular, the formation of neural networks and the functioning of synapses could be involved in the onset of ASD....
