by University of Basel Clinical Characterization of Patients Seropositive for Myelin Oligodendrocyte Glycoprotein (MOG) Immunoglobulin (Ig) A A, Frequency of disease manifestations for patients with isolated MOG-IgA and MOG-IgG. B, Frequency of positive and negative cerebrospinal fluid (CSF)–specific oligoclonal bands (OCBs) in MOG-IgA seropositive multiple sclerosis (MS) compared with seronegative MS. C, Magnetic resonance imaging (MRI)...
Jacob Plieth The private group celebrates a double first for its mRNA-generated Car-T therapy in myasthenia gravis. Using Car-T therapy in autoimmune disease, beyond its natural habitat of oncology, has gained huge traction of late. But the prospect of having patients undergo burdensome chemo conditioning, while acceptable in cancer, might stifle serious uptake in chronic diseases....
By Sarah Moore Reviewed by Danielle Ellis, B.Sc. Comorbidities are common in people with lupus. The autoimmune disease increases the risk of complications such as cardiovascular disease, cancer, and even mental health illnesses. Here, we explore some of the most common comorbidities in lupus. Image Credit: SewCreamStudio/Shutterstock.com Lupus and cardiovascular disease Cardiovascular disease has emerged...
by Lucy Dickie, Okinawa Institute of Science and Technology Mice that have neuroinflammation caused by autoimmunity were treated with PEP. The results found that PEP-treated mice showed improved signs of recovery, in comparison to mice that weren’t treated with PEP. Credit: Tsung-Yen Huang (OIST) Scientists in Japan have revealed a chemical compound that could be...
GARVAN INSTITUTE OF MEDICAL RESEARCH IMAGE: 2-PHOTON MICROSCOPE IMAGE OF THE GERMINAL CENTRE INSIDE A LYMPH NODE, SHOWING B CELLS (GREEN) MOVING AROUND AND A TINGIBLE BODY MACROPHAGE (RED) GRABBING THE DEAD AND DYING B CELLS CREDIT: GARVAN For almost 140 years, the origin and behaviour of an enigmatic cell type inside lymph nodes, called...
by University Health Network Credit: Pixabay/CC0 Public Domain Scientists at the Krembil Brain Institute, part of the University Health Network, have proposed a new mechanistic model (AD2) for Alzheimer’s, looking at it not as a brain disease, but as a chronic autoimmune condition that attacks the brain. This novel research is published today, in Alzheimer’s &...
by European Lung Foundation Portrait of researcher Dr Manali Mukherjee. Credit: Dr Manali Mukherjee / European Respiratory Society Blood samples drawn from patients with long COVID who are still suffering from fatigue and shortness of breath after a year show signs of autoimmune disease in those patients, according to a study published today in the European...
by American Heart Association Credit: Pixabay/CC0 Public Domain After a heart attack, people with an autoimmune disease were more likely to die, develop heart failure or have a second heart attack compared to people without an autoimmune disease, according to new research published today in the Journal of the American Heart Association. Autoimmune diseases, such as rheumatoid...
JoAnn E. Manson, MD, DrPH February 16, 2022 Hello. This is Dr JoAnn Manson, professor of medicine at Harvard Medical School and Brigham and Women’s Hospital. I’d like to talk about recent promising research from the vitamin D and omega-3 in the prevention of autoimmune diseases (VITAL) trial, recently published in The BMJ . We tested vitamin D 2000...
Between 5-8% of the human genome consists of sequences with the viral origin, namely endogenous retroviruses. These are old pieces of viral genomes that once, millions of years ago, infected our cells and branded them with their DNA sequences. Although endogenous retroviruses no longer code for viral proteins they were once intended to build, their RNA...
