by American Physiological Society Effect on EAE of Npnt neutralization by the Npnt-blocking antibody. A: Npnt concentration in plasma samples from EAE mice. *P < 0.05 vs. 0 day after MOG immunization. n = 4–7 in each group. B: protocol for EAE induction with Npnt-blocking antibody treatment (top). Disease severity scores of the EAE mice...
by Garvan Institute of Medical Research Strands of DNA. Credit: Dr. Kate Patterson, Garvan Institute of Medical Research Most autoimmune diseases are easy to diagnose but hard to treat. A paper published today in Science proposes using your unique immune cell fingerprint to rapidly identify which treatments will work for your autoimmune disease. “We analyzed the genomic...
BMJ Long term exposure to air pollution is linked to a heightened risk of autoimmune disease, particularly rheumatoid arthritis, connective tissue and inflammatory bowel diseases, finds research published online in the open access journal RMD Open. Environmental air pollution from vehicle exhaust and industrial output can trigger adaptive immunity–whereby the body reacts to a specific disease-causing...
by CU Anschutz Medical Campus Credit: CC0 Public Domain Researchers at the University of Colorado Anschutz Medical Campus have discovered that having one kind of autoimmune disease can lead to another. The scientists serendipitously found that mice with antibody-induced rheumatoid arthritis in their joints went on to develop spinal lesions similar to those in axial spondyloarthritis (AxSpA)...
Instead of searching for proteins that the immune system reacts against in a specific autoimmune disease, researchers have taken the opposite approach to find diseases linked to a certain protein. By searching among patients with various skin diseases, they identified a disease linked to autoimmunity against the skin protein TGM1. The strategy, which is presented...
Scientific animation helps illustrate how the immune system turns from helper to adversary. If a picture is worth a thousand words, moving pictures are worth millions. This is the case for scientific animations, where visual representations of processes and principles help students, researchers, and the general community understand and communicate complex ideas. But such visual...
UNIVERSITY OF CONNECTICUT IMAGE: LAIJUN LAI, RESEARCH PROFESSOR IN THE COLLEGE OF AGRICULTURE, HEALTH AND NATURAL RESOURCES AT THE UNIVERSITY OF CONNECTICUT. CREDIT: UCONN PHOTO The immune system is a complex balancing act; if it overreacts or underreacts to foreign molecules, there can be serious health consequences. For cancer patients, tumor progression is often accompanied...
WILEY The US prevalence of the autoimmune disease lupus is 72.8 cases per 100,000 individuals, according to an analysis of population-based registries. The analysis, which is published in Arthritis & Rheumatology, found that the rate is 9 times higher for females than males (128.7 vs. 14.6 per 100,000), and it’s highest among American Indians/Alaska Natives and...
by University of California, Los Angeles Dr. Owen Witte, MD. Credit: UCLA Broad Stem Cell Research Center Scientists from the Eli and Edythe Broad Center of Regenerative Medicine and Stem Cell Research at UCLA have developed a technique that will enable researchers to more efficiently isolate and identify rare T cells that are capable of targeting viruses, cancer and other diseases. The...
UNIVERSITÉ LIBRE DE BRUXELLES Autoimmune diseases are diseases of “mistaken identity”, where the immune system – which is supposed to protect us against infectious diseases and neoplasias – mistakenly attacks and destroys components of our own body. The incidence of autoimmune diseases is increasing on a worldwide basis, and these diseases – including type 1...
