Researchers seek new therapies to stop immune diseases CINCINNATI CHILDREN’S HOSPITAL MEDICAL CENTER CINCINNATI – In a finding that could help lead to new therapies for immune diseases like multiple sclerosis and IBD, scientists report in the Journal of Experimental Medicine identifying a gene and family of proteins critical to the formation of mature and...
Tag: <span>Autoimmune Disease</span>
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New treatment may reverse celiac disease
New technology may be applicable to other autoimmune diseases and allergies NORTHWESTERN UNIVERSITY CHICAGO — Results of a new phase 2 clinical trial using technology developed at Northwestern Medicine show it is possible to induce immune tolerance to gluten in individuals with celiac disease. The findings may pave the way for treated celiac patients to...
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How IL-6 allows the immune response to develop for a key cell, the T follicular helper
These preclinical findings may have therapeutic potential for autoimmune diseases like lupus. UNIVERSITY OF ALABAMA AT BIRMINGHAM BIRMINGHAM, Ala. – The body’s immune response fights against infectious disease, and it safeguards against future infections through vaccination. However, if the immune response dysfunctions and attacks the body itself, it can cause autoimmune disease. Thus, a healthy...
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Type 1 diabetes: Genetic risk reflected in gut microbiome
By Ana Sandoiu Fact checked by Jasmin Collier New research finds differences in the gut microbiome of children who are at high genetic risk of developing type 1 diabetes. The findings suggest that certain species of bacteria may have a protective effect in autoimmune conditions. Type 1 diabetes is an autoimmune condition that can develop...
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Treating inflammation with inflammation
by Ana Gajic, St. Michael’s Hospital Scientists at the Keenan Research Centre for Biomedical Science (KRCBS) have uncovered a new potential approach to treat multiple types of autoimmune disease including arthritis in lab models. Two million Canadians live with autoimmune diseases, which are conditions such as arthritis or lupus that cause a body’s immune system...
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Identifying Biomarkers for Guillain–Barré Syndrome
Sponsored Content by Bruker BioSpin – NMR, EPR and Imaging Guillain-Barre syndrome is a rare autoimmune condition in which the immune system attacks peripheral nerves and damages the myelin insulation. Symptoms rapidly progress from pain to muscle weakness and even paralysis. Although Guillain-Barre usually affects the hands, feet, and limbs, it can be life-threatening when...
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Medication linked to increased risk of inflammatory bowel disease
WILEY Medications that target tumor necrosis factor alpha (TNFα), a protein involved in inflammation, have revolutionized the management of certain autoimmune diseases, but paradoxically, these agents might provoke the development of other autoimmune conditions. In an Alimentary Pharmacology & Therapeutics study of 17,018 individuals with autoimmune diseases who were treated with anti-TNFα medications–mostly infliximab, etanercept, and adalimumab–and...
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B cells off the rails early in lupus
by Quinn Eastman, Emory University New research on the autoimmune disease systemic lupus erythematosus (SLE) provides hints to the origins of the puzzling disorder. The results were published Monday in Nature Immunology. In people with SLE, their B cells—part of the immune system—are abnormally activated. That makes them produce antibodies that react against their own tissues, causing a variety of symptoms,...
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Discovery of new autoimmune disease triggered by testicular cancer
Scientists have discovered a new autoimmune disease that is specifically triggered by testicular cancer. Utilizing a newly developed diagnostic tool, the research revealed how the cancer can cause the immune system to target the brain, bringing on severe neurodegenerative disease. Neurological diseases are usually tracked by applying a bio-specimen sample from a patient to a...
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Scleroderma Support: Patients Find Help Online
Scleroderma is a rare autoimmune disease, affecting about 300,000 Americans, but for those it affects it can be challenging to manage. The disease is associated with chronic inflammation and fibrosis in the connective tissues and visibly results in hardening and tightening of the skin, among other symptoms. Depending on the severity, patients can also experience issues with internal organs....