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Illumination of immune checkpoint LAG3 ‘black box’ could yield new cancer and autoimmune therapies
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Illumination of immune checkpoint LAG3 ‘black box’ could yield new cancer and autoimmune therapies

by University of Pittsburgh In mice that express LAG3 (left image), accumulation of LAG3 at the immunological synapse in T cells lowers the pH, making conditions more acidic (green and blue) compared with less acidic (red) conditions in T cells from mice that do not express LAG3 (right image). Credit: Guy, C. et al. Nature Immunology (2022)...