by The Endocrine Society Researchers using the world’s largest twin registry to study seven autoimmune diseases found the risk of developing the seven diseases is largely inherited, but that some diseases are more closely related than others. These results will be presented Sunday at ENDO 2019, the Endocrine Society’s annual meeting in New Orleans, La. “These results...
Tag: <span>Autoimmune</span>
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Autoimmune disorders may up risk for carpal tunnel syndrome
Po-Cheng Hsu, M.D., from Taipei Veterans General Hospital in Taiwan, and colleagues used data from the Longitudinal Health Insurance Database 2015 from Taiwan’s National Health Insurance Research Database to examine the correlation between CTS and common autoimmune disorders (autoimmune rheumatic disease [ARD] and inflammatory bowel disease [IBD]). The researchers identified 3,291 ARD and IBD patients...
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Inflammation: Study explains loss of protective abilities of T cells
First author of the study Dr. Garima Garg (left) and Dr. Andreas Muschaweckh, two scientists of the Experimental Neurimmunology at TUM, are working with a flow cytometer (FACS, Fluorescence-Activated Cell Sorting). Credit: Astrid Eckert / Technical University of Munich (TUM) Regulatory T cells (Tregs) ensure that immune responses are not too strong and that inflammation...
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Researchers map previously unknown disease in children
Researchers correct genetic mutation that causes IPEX, a life–threatening autoimmune syndrome. Date:January 10, 2019Source:University of California – Los Angeles Health Sciences Summary:Researchers have created a method for modifying blood stem cells to reverse the genetic mutation that causes a life–threatening autoimmune syndrome called IPEX. UCLA researchers led by Dr. Donald Kohn have created a method for modifying blood stem cells to reverse the genetic mutation that causes a life–threatening autoimmune syndrome called IPEX. The gene therapy, which was tested in mice, is similar to the technique Kohn...
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Link between autoimmune, heart disease explained in mice
Immune cells cause cholesterol to be trapped in blood vessels WASHINGTON UNIVERSITY SCHOOL OF MEDICINE People with autoimmune diseases such as psoriasis, lupus and rheumatoid arthritis are at high risk of developing cardiovascular disease, even though none of these conditions seem to target the cardiovascular system directly. Now, researchers at Washington University School of Medicine...
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Cytokine levels could predict autoimmune reactions to cancer Immunotherapy
The development of immunotherapy, which mobilizes the body’s own immune system to destroy cancer cells, is one of the greatest advances in cancer treatment, but immunotherapy can cause harm to healthy tissue in some patients. Researchers at UT Southwestern have identified blood-based biomarkers that may help identify those patients at greatest risk of developing autoimmune...
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Destination: Personalized Disease Management Approaches for People with Autoimmune Diseases
A biomarker is a characteristic that can be objectively measured as an indicator of normal or pathologic biological processes, or as an indicator of response to therapy. As such, biomarkers have generated significant interest within the autoimmune disease research and medical communities because of their potential to help physicians make predictions about disease progression and to...
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Clues to lupus’s autoimmune origins in precursor cells
DN2 B cells expanded in SLE patients EMORY HEALTH SCIENCES In the autoimmune disease systemic lupus erythematosus or SLE, the immune system produces antibodies against parts of the body itself. How cells that produce those antibodies escape the normal “checks and balances” has been unclear, but recent research from Emory University School of Medicine sheds light...
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Exercising with rheumatoid arthritis
(HealthDay)—Different from osteoarthritis, which is the wear-and-tear breakdown of joint cartilage experienced over time, rheumatoid arthritis, or RA, is an autoimmune disease that causes both pain and intense fatigue. When you’re in the throes of a flare, exercise may seem like mission impossible and you might be advised to rest until it passes. But exercise...
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When the Body Attacks Itself
New research shows how the immune system’s interaction with viruses leads to autoimmune disease Viral infections can trigger the onset of debilitating autoimmune diseases. For example, in acute disseminated encephalomyelitis (ADEM), the body attacks a protein that protects nerves in the brain and spinal cord, often following a viral infection. However, how viral infections interact...