A group of researchers at the University of São Paulo (USP) in Brazil used a DNA editing tool called CRISPR/Cas9 to manipulate the genes associated with the autoaggressive T lymphocytes responsible for inducing autoimmune diseases such as autoimmune polyglandular syndrome type 1 (APS-1) and type 1 diabetes. Immunofluorescence image of mTECs, with cell nucleus highlighted in blue...
Tag: <span>Autoimmune</span>
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Link between autoimmune disorders and psychosis confirmed in new study
People with autoimmune disorders, a collection of diseases where the body’s immune system attacks its own cells, are more likely to have psychosis, according to our latest research. Lid retraction is a typical symptoms of Graves’ disease. Credit: Jonathan Trobe/Wikimedia Commons, CC BY Previous research found that rates of rheumatoid arthritis were lower in people with psychosis than would be expected in the general population....
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Human immune ‘trigger’ map paves way for better treatments
A discovery about how human cells are ‘triggered’ to undergo an inflammatory type of cell death could have implications for treating cancer, stroke and tissue injury, and immune disorders. IMAGE: A DISCOVERY ABOUT HOW HUMAN CELLS ARE 'TRIGGERED' TO UNDERGO AN INFLAMMATORY TYPE OF CELL DEATH COULD HAVE IMPLICATIONS FOR TREATING CANCER, STROKE AND TISSUE INJURY,...
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Predicting relapses in patients with autoimmune vascular disease
Patients with an autoimmune disorder called antineutrophil cytoplasmic antibody-associated vasculitis produce antibodies that damage blood vessels in the body. In some cases, patients’ antibodies target a protein called myeloperoxidase. New research published in Arthritis & Rheumatology indicates that for patients in remission, reappearance of antibodies against myeloperoxidase is a sign that patients will experience a relapse of...
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Drinking baking soda could be an inexpensive, safe way to combat autoimmune disease
A daily dose of baking soda may help reduce the destructive inflammation of autoimmune diseases like rheumatoid arthritis, scientists say. They have some of the first evidence of how the cheap, over-the-counter antacid can encourage our spleen to promote instead an anti-inflammatory environment that could be therapeutic in the face of inflammatory disease, Medical College...
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Study points to potential personalized approach to treating lupus
In individuals with lupus, immune cells attack the body’s own tissue and organs as if they are enemy invaders. A new Yale-led study describes how a protein found in common bacteria triggers that auto-immune response. The finding opens the door to future therapies targeting the bacteria rather than the immune system, the researchers said. To...