TOKYO METROPOLITAN INSTITUTE OF MEDICAL SCIENCE DAMAGED MITOCHONDRIA ARE SELECTIVELY ELIMINATED VIA AUTOPHAGY CALLED MITOPHAGY. IN MAMMALIAN CELLS, UBIQUITIN CHAINS ON THE DAMAGED MITOCHONDRIA PLAY CRITICAL ROLES TO INDUCE MITOPHAGY. Researchers at TMIMS have revealed that PINK1 (a serine/threonine kinase) and Parkin (a ubiquitin ligating enzyme: E3) work together to ubiquitylate the outer membrane proteins...
Monash researchers have unlocked a key process in all human cells that contributes to diseases like cancer and neurodegenerative diseases as well as ageing. The discovery reveals how cells efficiently get rid of cellular junk, which when it accumulates, can trigger death and the health problems associated with getting older. IMAGE: THE IMAGE SHOWS CELLS...
Synthesised curcumin analog C1 specifically binds to TFEB and promotes its nuclear translocation, and then activates autophagy and lysosome biogenesis to degrade alpha-synuclein. A research team led by Professor Li Min, Director of the Teaching and Research Division (CMTR), and Director of the Mr and Mrs Ko Chi Ming Centre for Parkinson’s Disease Research...
