by Hong Kong University of Science and Technology In CNS, such as retinal ganglion cells, IFNγ activates STAT1 in Ptpn2 cKO RGCs. STAT1 then upregulates neuronal cGAS expression. cGAS produces cGAMP and activate STING in neurons. In PNS, such as dorsal root ganglion, axotomy induces IFNγ expression in axons by local translation. And IFNγ activates...
by Hong Kong University of Science and Technology Typical examples include paralysis due to a spinal cord injury and visual field atrophy, or even complete blindness due to optic nerve atrophy in glaucoma patients. Therefore, in-depth study of the basic biological processes that affect axon regeneration is particularly important for human health. Traditional research on...
