by University of Pittsburgh Credit: Pixabay/CC0 Public Domain A group of University of Pittsburgh researchers has given new meaning to “knowing your ABCs.” In a new study, published in the Journal of Experimental Medicine, the team showed that a type of immune cell called age-associated B cells, or ABCs, are important drivers of lupus and that targeting these...
by Rockefeller University Graphical abstract. Credit: Cell (2022). DOI: 10.1016/j.cell.2022.11.031 If B cells are the munitions factories of the immune system, manufacturing antibodies to neutralize harmful pathogens, then the tiny biological structures known as germinal centers are its weapons-development facilities. Formed in response to infection and vaccination, these microscopic training grounds allow B cells to perfect the...
by Rockefeller University Press Compared with a control (left), treatment with a soluble BCMA decoy receptor (right) increases the number of dying cancer cells (brown) in a multiple myeloma tumor growing in mice. Credit: © 2022 Miao et al. Originally published in Journal of Experimental Medicine. 10.1084/jem.20220214 Researchers at Stanford University have developed “decoy receptor” molecules that...
by Massachusetts General Hospital 3D rendering of a B cell. Credit: Blausen.com staff (2014). “Medical gallery of Blausen Medical 2014”. WikiJournal of Medicine 1 (2). DOI:10.15347/wjm/2014.010. ISSN 2002-4436. CC BY-SA 4.0 B cells are the immune cells responsible for creating antibodies, and most B cells, known as B2 cells, produce antibodies in response to a pathogen...
