NEWS RELEASE 16-MAY-2024 B cells drive responses of other immune cells, and can be modified to prevent Multiple Sclerosis symptomsAbnormally active B cell metabolism causes an inflammatory immune response in individuals with MS, Penn Medicine research finds Peer-Reviewed PublicationUNIVERSITY OF PENNSYLVANIA SCHOOL OF MEDICINE IMMUNE CELL INTERACTIONS DRIVING MS ATTACKS. CREDIT: PENN MEDICINE PHILADELPHIA –...
by King’s College London Spatial transcriptomic coupled with high throughput intratumoral antibody repertoire analyses suggest an active but aberrant B cell response. a Representative image of spatial transcriptomic deconvolution of B cells, T cells and B cell germinal center (GC) signatures. Top panels, signature score per spot; bottom panels, binarized values using 50% (B cells and T cells)...
by Ludwig Maximilian University of Munich Regulation and function of GPR55 signaling in atherosclerosis. a–d, Plasma, spleens and aortic roots were collected from Apoe−/− mice at baseline or after 4 weeks and 16 weeks of WD to determine LPI plasma concentrations (n = 7–8; *P = 0.05 and ***P = 0.0042) (a) or relative splenic mRNA expression of the gene encoding the LPI-synthesizing enzyme...
by RIKEN Fig. 1: Metabolic remodeling of immunized LNs and B cell-dependent GABA production. a–e, Mice were injected in the foot pad with OVA + CFA, and iLNs and cLNs were collected for metabolite MS and histology at day 7: WT (n = 11), Cd3–/– (n = 5), muMt–/– (n = 4) and Rag1–/– (n = 3). a, Immunohistochemistry of B cells (B220), T cells (CD3)...
by Weill Cornell Medical College Credit: Blausen Medical, CC BY-SA 4.0 The master regulator behind the development of antibody-producing cells has been identified in a study by investigators at Weill Cornell Medicine. The findings provide new insight into the inner workings of the immune system and may help understand how tissues develop and how certain...
UNIVERSITY OF MÜNSTER IMAGE: DIFFERENT TYPES OF WHITE BLOOD CELLS FOUND IN THE OUTER LAYER OF THE MENINGES OF MICE. EXAMINING AROUND 3,000 CELLS, SCIENTISTS ANALYSED WHICH GENES ARE ACTIVE IN EVERY SINGLE CELL AND IDENTIFIED 19 DIFFERENT CELL TYPES. ONE DOT CORRESPONDS TO AN INDIVIDUAL CELL. THE CLOSER THE DOTS ARE TO EACH OTHER,...
The immune system becomes disordered and dysfunctional with age in numerous different ways. The B cell component accumulates inflammatory and problematic cells that are known as age-associated B cells. Here, researchers show that these errant B cells produce antibodies that provoke autoimmunity. B cell aging is a problem with a solution demonstrated in animal models: just destroy all B cells. Mammals can get by without B...
by Delthia Ricks , Medical Xpress Identification and flow cytometric delineation of positively selected cMyc+ GC B cell subpopulations. (A) scRNAseq workflow and gating strategy for isolating splenic cMyc+ GC B cells of cMycgfp/gfp mice. (B) Heat map illustrating highly representative DEGs in each cluster. These DEGs passed thresholds: first, the cutoff for P ≤...
