October 3, 2024 by Rockefeller University Recall germinal centers formed in response to a secondary infection generate a second line of defense, rebuffing memory B cells in favor of training naive ones. Credit: Rockefeller UniversityCertain infectious diseases, such as COVID or the flu, evolve constantly, shapeshifting just enough to outmaneuver our immune systems and reinfect...
Tag: <span>B cells</span>
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Here’s why B cells benefit from booster shots
Recall germinal centers formed in response to a secondary infection generate a second line of defense, rebuffing memory B cells in favor of training naive ones. Credit: Rockefeller University Certain infectious diseases, such as COVID or the flu, evolve constantly, shapeshifting just enough to outmaneuver our immune systems and reinfect us repeatedly. But subsequent reinfections...
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Researchers turn the body’s B cells into tiny surveillance machines, antibody factories
JULY 22, 2024 by Leigh Hopper, University of Southern California Genome editing at the constant region of the IgH locus. a, Antibody H chains are encoded by a rearranged variable domain (VH) spliced to a constant region that can be altered by class switch recombination. b, K562 cells were edited with Cas9 RNPs programmed by...
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B cells drive responses of other immune cells, and can be modified to prevent Multiple Sclerosis symptoms
NEWS RELEASE 16-MAY-2024 B cells drive responses of other immune cells, and can be modified to prevent Multiple Sclerosis symptomsAbnormally active B cell metabolism causes an inflammatory immune response in individuals with MS, Penn Medicine research finds Peer-Reviewed PublicationUNIVERSITY OF PENNSYLVANIA SCHOOL OF MEDICINE IMMUNE CELL INTERACTIONS DRIVING MS ATTACKS. CREDIT: PENN MEDICINE PHILADELPHIA –...
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Study uncovers how B cells react to skin cancer
by King’s College London Spatial transcriptomic coupled with high throughput intratumoral antibody repertoire analyses suggest an active but aberrant B cell response. a Representative image of spatial transcriptomic deconvolution of B cells, T cells and B cell germinal center (GC) signatures. Top panels, signature score per spot; bottom panels, binarized values using 50% (B cells and T cells)...
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Atherosclerosis: How the body controls the activity of B cells
by Ludwig Maximilian University of Munich Regulation and function of GPR55 signaling in atherosclerosis. a–d, Plasma, spleens and aortic roots were collected from Apoe−/− mice at baseline or after 4 weeks and 16 weeks of WD to determine LPI plasma concentrations (n = 7–8; *P = 0.05 and ***P = 0.0042) (a) or relative splenic mRNA expression of the gene encoding the LPI-synthesizing enzyme...
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GABA released by B-cells blunts the immune response to tumors
by RIKEN Fig. 1: Metabolic remodeling of immunized LNs and B cell-dependent GABA production. a–e, Mice were injected in the foot pad with OVA + CFA, and iLNs and cLNs were collected for metabolite MS and histology at day 7: WT (n = 11), Cd3–/– (n = 5), muMt–/– (n = 4) and Rag1–/– (n = 3). a, Immunohistochemistry of B cells (B220), T cells (CD3)...
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Antibody-producing b cells may be ‘predestined’ for their fates
by Weill Cornell Medical College Credit: Blausen Medical, CC BY-SA 4.0 The master regulator behind the development of antibody-producing cells has been identified in a study by investigators at Weill Cornell Medicine. The findings provide new insight into the inner workings of the immune system and may help understand how tissues develop and how certain...
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B cells of the immune system discovered in the meninges
UNIVERSITY OF MÜNSTER IMAGE: DIFFERENT TYPES OF WHITE BLOOD CELLS FOUND IN THE OUTER LAYER OF THE MENINGES OF MICE. EXAMINING AROUND 3,000 CELLS, SCIENTISTS ANALYSED WHICH GENES ARE ACTIVE IN EVERY SINGLE CELL AND IDENTIFIED 19 DIFFERENT CELL TYPES. ONE DOT CORRESPONDS TO AN INDIVIDUAL CELL. THE CLOSER THE DOTS ARE TO EACH OTHER,...
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Age-Associated B Cells in Immunosenescence
The immune system becomes disordered and dysfunctional with age in numerous different ways. The B cell component accumulates inflammatory and problematic cells that are known as age-associated B cells. Here, researchers show that these errant B cells produce antibodies that provoke autoimmunity. B cell aging is a problem with a solution demonstrated in animal models: just destroy all B cells. Mammals can get by without B...
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