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‘Bad’ cholesterol gene silenced without altering the DNA sequence
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‘Bad’ cholesterol gene silenced without altering the DNA sequence

By Paul McClure Epigenetic editing has been used to silence a cholesterol-regulating gene in miceAI-generated by DALL-E By silencing the gene responsible for regulating ‘bad’ cholesterol without altering the primary DNA sequence, researchers have shown that it’s possible to use epigenetic editing to treat diseases rather than conventional DNA-breaking gene editing technology, which risks unintended effects....

Haywire T cells attack protein in “bad” cholesterol
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Haywire T cells attack protein in “bad” cholesterol

by La Jolla Institute for Immunology T cells may drive inflammation as dangerous plaques build up in the cardiovascular system. Image from La Jolla Institute for Immunology. Credit: La Jolla Institute for Immunology Preventing atherosclerosis, the underlying cause of heart disease, means scientists need to understand how immune cells drive inflammation in the arteries. The challenge is that the T cells involved...

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Researchers have warned statins offer no protection to millions of people

‘No evidence’ having high levels of bad cholesterol causes heart disease, claim 17 cardiologists as they call on doctors to ‘abandon’ statins Researchers have warned statins to offer no protection to millions of people The findings add to the ever-growing row over the cholesterol-busting pills High levels of LDL-C has been considered a major cause of...