Super-precise gene-editing approach switches off a gene in the liver that regulates ‘bad’ cholesterol. Miryam Naddaf Cholesterol crystals (red) in a lipid droplet in a human liver.Credit: Steve Gschmeissner/Science Photo Library The first trial in humans of the precise gene-editing technique known as base editing has shown promising results for keeping cholesterol levels in check....
Tag: <span>Base editing</span>
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RNA Editing Possible with CRISPR-Cas13
Scientists extend the capabilities of the CRISPR-Cas system to include precise manipulations of RNA sequences in human cells. WIKIMEDIA, NICOLLE RAGER, NATIONAL SCIENCE FOUNDATION Fusing an RNA-editing enzyme to an RNA-targeting Cas protein has enabled researchers to edit specific nucleotides within RNA molecules in human cells. The approach, called RNA Editing for Programmable A-to-I replacement (REPAIR),...