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Vitamin B6 deficiency enhances the noradrenergic system, leading to behavioral deficits
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Vitamin B6 deficiency enhances the noradrenergic system, leading to behavioral deficits

TOKYO METROPOLITAN INSTITUTE OF MEDICAL SCIENCE IMAGE: (A) VB6(-) mice showed hyperactivate noradrenergic (NAergic) signaling, resulting in behavioral deficits comparable to schizophrenia. (B) These are ameliorated by VB6 supplementation into the brain or treatment with the 2A adrenoreceptor agonist guanfacine (GFC), which suppresses NA release. CREDIT: TMIMS Schizophrenia is a heterogeneous psychiatric disorder characterized by...