by Katrin Boes, Max Planck Society Wnt4 expression in islets. a Reporter constructs monitoring Wnt4 expression (Wnt4eGFPCre) and used for lineage tracing (Wnt4eGFPCre; mTmG). Expression pattern of Wnt4 revealed by mGFP immunostaining in Wnt4eGFPCre Tg+; mTmG Tg+ islets at E18.5 (b, c), P0 (d), P5 (e) and 8 weeks (f). DAPI marks the nucleus, Insulin β-cells, Glucagon α cells, as color-encoded....
Tag: <span>beta-cell</span>
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Researchers develop pancreatic beta-cell restoring therapy for treating type 1 diabetes
by The Endocrine Society A pancreatic islet from a mouse in a typical position, close to a blood vessel; insulin in red, nuclei in blue. Credit: Generated in the Solimena lab, Paul Langerhans Institute Dresden Researchers have successfully treated type 1 diabetes in mice using pancreatic beta-cell, target-specific, chimeric antigen-receptor (CAR) regulatory T cells (Tregs), and...