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Distant relatedness in biobanks harnessed to identify undiagnosed genetic disease

September 28, 2024 by Leigh MacMillan, Vanderbilt University Medical Center This tool identifies groups of people who share an IBD segment spanning a specific genomic region (in this study, the gene KCNE1). A DRIVE first selects the pairwise IBD segments spanning the target gene/variant among clinic samples and biobank subjects. B DRIVE uses a random...