MAY 31, 2024 by Washington University in St. Louis Credit: Pixabay/CC0 Public Domain The protein sTREM2 plays a crucial role in Alzheimer’s disease, but the role is complex and poorly understood. In the early stages of the disease, sTREM2 levels in the cerebrospinal fluid fall relative to healthy people’s, but then the levels rise far...
Yale investigators from the cardiovascular medicine section have identified a new artificial intelligence (AI)-based video biomarker to identify those who might develop and have rapidly worsening aortic stenosis.This research was highlighted in a new paper, “A Multimodality Video-Based AI Biomarker For Aortic Stenosis Development And Progression,” published in JAMA Cardiology. More than 1.5 million people...
by University of Cambridge Credit: Pixabay/CC0 Public DomainSARS-CoV-2 triggers the production of the antiviral protein IFN-γ, which is associated with fatigue, muscle ache and depression. New research shows that in long COVID patients, IFN-y production persists until symptoms improve, highlighting a potential biomarker and a target for therapies. A University of Cambridge-led study identifies the protein...
By Paul McClure Researchers have identified a biomarker that can accurately diagnose gastric cancerDepositphotos Researchers have identified a blood protein that can be used as a marker of gastric and other cancers and is more accurate than existing diagnostic biomarkers, even in the early stages of the disease. The simple test may lead to the earlier...
by Washington University School of Medicine Kanta Horie, PhD, works with a mass spectrometer that he uses to measure protein levels in cerebrospinal fluid samples. Horie and colleagues at Washington University School of Medicine in St. Louis and Lund University in Sweden have discovered that a form of the protein tau in the cerebrospinal fluid known...
by University of Pittsburgh Credit: Pixabay/CC0 Public Domain Why do some people develop Alzheimer’s disease while others don’t? And, even more puzzlingly, why do many individuals whose brains are chock-full of toxic amyloid aggregates—a telltale sign of Alzheimer’s brain pathology—never go on to develop Alzheimer’s-associated dementias? University of Pittsburgh School of Medicine researchers appear to have...
by Josh Barney, University of Virginia The discovery of how tau tangles form in Alzheimer’s brains could lead to treatment breakthroughs. Credit: Emily Faith Morgan, University Communications University of Virginia neuroscientists have revealed how a toxic form of tau protein, notorious for forming tangles in the brains of people with Alzheimer’s disease and several other...
by Duke University Azithromycin antibiotics prescription. Credit: Tony Webster/Wikimedia Commons, CC BY-SA Testing for procalcitonin, a blood biomarker that is increased in people with a bacterial infection, could help physicians more quickly and effectively determine whether patients need antibiotics. Knowing that would ultimately reduce the rate of unnecessary antibiotic use, according to a new study from Duke Health...
by Johannes Angerer, Medical University of Vienna Graphical abstract. Credit: Journal of Hepatology (2022). DOI: 10.1016/j.jhep.2022.06.004 A MedUni Vienna study team has identified the role of a specific subtype of macrophages (white blood cells) in progressive non-alcoholic fatty liver disease. As part of the immune system, these cells have a protective function against fibrosis and liver cirrhosis. At...
by Kobe University Figure 1: Disease onset and changes in P450 expression. Credit: Kobe University Researchers at Kobe University and Hiroshima University have successfully developed a biomarker that will enable Parkinson’s disease to be rapidly and inexpensively diagnosed from blood serum samples. It is hoped that being able to diagnose the disease faster will also lead...
