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Tumors with specific genetic mutations show response to immune checkpoint blockade therapy
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Tumors with specific genetic mutations show response to immune checkpoint blockade therapy

by Cleveland Clinic Immune microenvironment of the post-treatment Pole mutant tumors. a, Differentially expressed genes up-regulated or down-regulated in the post-ICB PoleP286R tumors versus the parental tumors. There are 82 DEGs that are consistently upregulated in all ICB treatment arms, while there are 59 genes are consistently downregulated in mutant tumors of all immune checkpoint...