by Weizmann Institute of Science Credit: EMBO Molecular Medicine (2024). DOI: 10.1038/s44321-023-00020-yWeizmann Institute scientists have discovered two small molecules that can cross the blood-brain barrier in mice, slowing and even reversing the effects of Huntington’s, which is incurable. The human brain is a well-guarded control center. Its system of blood vessels is surrounded by a densely...
by Universitätsklinikum Bonn In the microscope image, astrocytes are stained green and immune cells are stained red. The basement membranes of the vessels are seen in white. Credit: University of Münster / University Hospital Bonn (UKB) Researchers have identified novel gelatinase substrates involved in astroglial barrier function. In neuroinflammation, immune cells such as leukocytes cross the...
by Lori Dajose, California Institute of Technology CA-IV is required for the CNS potency of Car4-dependent AAV. (A) Immunostaining for CA-IV in the brains of WT/WT and KO/KO Car4 mice. Magnified regions from WT/WT demonstrate endothelial expression across diverse brain regions. (B) AAV-PHP.eB, 9P31, and 9P36 packaging mNeonGreen under the control of the ubiquitous CAG promoter...
by Vinzenz Greiner, ETH Zurich In order to better understand how the blood-brain barrier protects our central nervous system from harmful substances in the bloodstream, ETH researchers have developed a new in-vitro model. Credit: Gunilla Elam / Science Photo Library Up to now, the use of models to research the barrier that separates the circulatory...
by Inka Väth, University of Bonn Monitoring the pharmacological effect on neuronal responses after drug passage through the BBB. a Time course of an example experiment of fEPSP recordings in the hippocampal area CA1. The adenosine A1-receptor CPA reduces synaptic responses. This effect is antagonized by co-application of caffeine. Inset shows recordings (average of 5...
In their new study, the researchers show how a modified peptide, in mice, helps a cancer drug pass through the blood-brain barrier, which is known to be extremely difficult to penetrate and thus serves as a massive hindrance to treating brain tumors. “We were not only able to get a drug into the brain, but...
Tested using a new brain tissue model, the particles may be able to deliver chemotherapy drugs for glioblastoma. There are currently few good treatment options for glioblastoma, an aggressive type of brain cancer with a high fatality rate. One reason that the disease is so difficult to treat is that most chemotherapy drugs can’t penetrate...
NAGOYA CITY UNIVERSITY IMAGE: BBB KW MAP (A), QSM (B), AND [11C]PIB-PET SUVR (C) FROM AN APOE Ɛ4 NONCARRIER (Ε3/Ε3), A HETEROZYGOTE (Ε3/Ε4), AND A HOMOZYGOTE (Ε4/Ε4) ARE DISPLAYED. CREDIT: NAGOYA CITY UNVIERSITY Alzheimer’s disease (AD) is the most common type of dementia. An etiology of AD would be excessive accumulation of toxic forms of...
by Isabella Backman, Yale University Fig. 1: Endothelial Unc5B controls BBB integrity. a Unc5B gene deletion strategy using tamoxifen injection in adult mice. b Immunofluorescence staining with the indicated antibodies and confocal imaging of adult brain sections at P67, 30 min after i.v cadaverine injection and reproduced on n = 4 Unc5Bfl/fl and n = 5 Unc5BiECko brains. c Quantification of...
by Université libre de Bruxelles Repurposing Wnt7a ligands into BBB therapeutics.BBB dysfunction has been implicated in the etiology of a large set of CNS disorders. Wnt7a/b ligands, which dominate the neurovascular differentiation cascade during vertebrate development, are here repurposed as safe BBB therapeutics by engineering them into highly specific Gpr124/Reck agonists. [Illustration created with BioRender]....
