Tag: <span>blood brain barrier</span>

by Justin Jackson , Phys.org Intranasal delivery of recombinant appetite-regulating hormones by engineered Lp. Credit: Cell (2025). DOI: 10.1016/j.cell.2025.01.017 Researchers at the National University of Singapore have reported crossing the blood–brain barrier with help from a modified Lactobacillus plantarum. By delivering an appetite-regulating hormone directly to the olfactory epithelium, the hormone was able to reach its target....

by Texas Tech University Credit: Fluids and Barriers of the CNS (2024). DOI: 10.1186/s12987-024-00584-y For decades, scientists across the globe have investigated methods to accurately measure drug permeability across the blood-brain barrier, a compact layer of cells that protect the brain from potentially dangerous substances and microbes. They struggled with a number of parameters, such as blood flow...

Peer-Reviewed Publication The Mount Sinai Hospital / Mount Sinai School of Medicine image:  Brain barrier-crossing conjugates enable the systemic delivery of large therapeutic molecules to the brain. Credit: Lab of Yizhou Dong, PhD, at Icahn Mount Sinai. New York, NY [November 25, 2024]—Researchers at the Icahn School of Medicine at Mount Sinai have developed an...

by Tiziano Balzano Low-intensity focused ultrasound, combined with circulating microbubbles, opens new doors for delivering targeted therapies into the brain. Credit: Tiziano Balzano, created using Canva’s AI image generator Neurological disorders such as Alzheimer’s and Parkinson’s disease are among the most debilitating and life-altering conditions that we face today. Despite years of research and advancements...

Getting drugs to the brain is difficult. The very thing designed to protect the brain’s environment — the blood-brain barrier (BBB), tightly packed cells that prevent most substances from passing through — is one of the main reasons diseases like Alzheimer’s are so hard to treat. And even if a drug can cross the BBB,...